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Chemical Structure| 1350648-20-2 Chemical Structure| 1350648-20-2

Structure of 1350648-20-2

Chemical Structure| 1350648-20-2

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Product Details of [ 1350648-20-2 ]

CAS No. :1350648-20-2
Formula : C6H4IN3
M.W : 245.02
SMILES Code : IC1=C(NN=C2)C2=NC=C1

Safety of [ 1350648-20-2 ]

Application In Synthesis of [ 1350648-20-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1350648-20-2 ]

[ 1350648-20-2 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 558-42-9 ]
  • [ 1350648-20-2 ]
  • [ 1350648-61-1 ]
YieldReaction ConditionsOperation in experiment
43.8% With caesium carbonate; In N,N-dimethyl-formamide; at 120℃; for 0.5h;Microwave irradiation; [0157] 7-Iodo-2H-pyrazolo[4,3-b]pyridine (300 mg, 1.224 mmol), l-chloro-2-methylpropan- 2-ol (133 mg, 1.224 mmol) and CS2CO3 (399 mg, 1.224 mmol) were combined in DMF (5 mL). The mixture was heated at 120 °C for 30 minutes using a microwave. The reaction mixture was then purified by preparative HPLC using a Sunfire Prep 5muiotaeta CI 8, 75 X 30 mm column eluting with a gradient of 05 - 25percent acetonitrile (containing 0.035percent TFA) in water (containing 0.05percent> TFA) using basic buffer to afford l-(7-iodo-2H-pyrazolo[4,3-b]pyridin- 2-yl)-2-methylpropan-2-ol (170 mg, 0.536 mmol, 43.8 percent yield). MS [M+H] found 318.
  • 2
  • [ 35979-69-2 ]
  • [ 1350648-20-2 ]
  • [ 1350649-19-2 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 120℃; for 1h;Microwave irradiation; [0353] 7-Iodo-2H-pyrazolo[4,3-b]pyridine (342 mg, 1.396 mmol), 4-bromo-2-methylbutan- 2-ol (233 mg, 1.396 mmol) and CS2CO3 (455 mg, 1.396 mmol) were combined in DMF (5 mL) and heated in a microwave at 120 C for 60 minutes. The reaction was cooled, filtered, and concentrated to give a residue which was purified by silica column eluted using a step gradient of EtOAc (0-90%) in hexanes to give 4-(7-iodo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2- methylbutan-2-ol.
  • 3
  • [ 35979-69-2 ]
  • [ 1350648-20-2 ]
  • [ 1350649-19-2 ]
  • [ 1350649-20-5 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 120℃; for 1h;Microwave irradiation; [0350] 7-Iodo-2H-pyrazolo[4,3-b]pyridine (342 mg, 1.396 mmol), 4-bromo-2-methylbutan- 2-ol (233 mg, 1.396 mmol) and CS2CO3 (455 mg, 1.396 mmol) were combined in DMF (5 mL) and heated in a microwave at 120 C for 60 minutes. The reaction was cooled, filtered, and concentrated to give a residue which purified on a silica column and eluted using a step gradient of EtOAc (0-90%) in hexanes to give 4-(7-iodo-2H-pyrazolo[4,3-b]pyridin-2-yl)-2- methylbutan-2-ol and 4-(7-iodo-lH-pyrazolo[4,3-b]pyridin-l-yl)-2-methylbutan-2-ol.
  • 4
  • [ 35979-69-2 ]
  • [ 1350648-20-2 ]
  • [ 1350649-20-5 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 120℃; for 0.666667h;Microwave irradiation; [0379] 7-Iodo-2H-pyrazolo[4,3-b]pyridine (357 mg, 1.457 mmol), 4-bromo-2-methylbutan- 2-ol (243 mg, 1.457 mmol) and Cs2C03 (475 mg, 1.457 mmol) were combined in DMF (5 mL) and heated in a microwave at 120 C for 40 minutes. The reaction was then cooled, filtered, and concentrated to give a residue which was purified by silica chromatography eluted with a step gradient of EtOAc in hexanes to give 4-(7-iodo-lH-pyrazolo[4,3- b]pyridin-l-yl)-2-methylbutan-2-ol which was dried and used immediately.
  • 5
  • [ 35979-69-2 ]
  • [ 1350648-20-2 ]
  • 4-(7-(3'-fluoro-6'-methyl-2,2'-bipyridin-4-ylamino)-1H-pyrazolo[4,3-b]pyridin-1-yl)-2-methylbutan-2-ol [ No CAS ]
 

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