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Chemical Structure| 1351997-20-0 Chemical Structure| 1351997-20-0

Structure of 1351997-20-0

Chemical Structure| 1351997-20-0

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Product Details of [ 1351997-20-0 ]

CAS No. :1351997-20-0
Formula : C10H13NO
M.W : 163.22
SMILES Code : O[C@@H]1CC[C@H](N)C2=C1C=CC=C2
MDL No. :MFCD28502595

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Application In Synthesis of [ 1351997-20-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1351997-20-0 ]

[ 1351997-20-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-62-2 ]
  • [ 1351997-20-0 ]
  • [ 1443243-08-0 ]
YieldReaction ConditionsOperation in experiment
52% a. 5-((lR,4S)-4-Amino-l,2,3,4-tetrahydro-naphthalen-l-yloxy)- pyridine-2-carbonitrile (Intermediate 9a) Intermediate A (300 mg, 1.84 mmol) was added to an ice cold stirred suspension of sodium hydride (60% in mineral oil, 221 mg, 5.52 mmol) in DMF (15 mL) and stirred for 15 min. 2-Cyano-5-fluoropyridine (224 mg, 1.84 mmol) was added and the reaction warmed to RT. After 90 min, the reaction was quenched by dropwise addition of water and the mixture partitioned between EtOAc (75 mL) and water (150 mL). The aqueous layer was then extracted with EtOAc (3 x). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-5% [2M NH3 in MeOH] in DCM, to give the title compound (255 mg, 0.96 mmol, 52%). LCMS (Method 4): Rt 0.28, 1.73, m/z 266.1 [MH+].
 

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