1353637-44-1|6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine| Ambeed

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Quality Control of [ 1353637-44-1 ] Purity: 98+% SDS Specification

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Product Details of [ 1353637-44-1 ]

CAS No. :	1353637-44-1
Formula :	C₁₁H₁₂ClN₃O
M.W :	237.69
SMILES Code :	ClC1=CC(N(C2CCCCO2)N=C3)=C3C=N1
MDL No. :	MFCD20926787
InChI Key :	OUIMHYFRCMWCEA-UHFFFAOYSA-N
Pubchem ID :	71463635

Safety of [ 1353637-44-1 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Application In Synthesis of [ 1353637-44-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1353637-44-1 ]

[ 1353637-44-1 ] Synthesis Path-Downstream 1~1

1
[ 1353637-44-1 ]
[ 365564-07-4 ]
[ 1614233-84-9 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In 1,4-dioxane; water; at 90℃; for 2h;Sealed tube;	A mixture of 6-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine (0.80 g, 3.4 mmol) (Example 24, Step 1), <strong>[365564-07-4]2-(3,5-dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane</strong> (1.1 g, 4.0 mmol), [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complexed with dichloromethane (1:1) (200 mg, 0.3 mmol), and potassium phosphate (1400 mg, 6.7 mmol) in 1,4-dioxane (7 mL) and water (1 mL) in a reaction vial was degassed and sealed. It was stirred at 90 C. for 2 h. After cooling it was concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%) to afford the desired product (660 mg). LCMS (M+H)+=340.1.

References: [1]Patent: US2014/171405,2014,A1 .Location in patent: Paragraph 0305.

Historical Records

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 1353637-44-1 ]

Chlorides

A342899 [1416713-66-0]

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A654398 [1416712-71-4]

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Related Parent Nucleus of
[ 1353637-44-1 ]

Other Aromatic Heterocycles

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A654398 [1416712-71-4]

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Tetrahydropyrans

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Similarity: 0.87

A654398 [1416712-71-4]

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A467995 [1416713-73-9]

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CAS No.: 1353637-44-1

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