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Chemical Structure| 1354355-91-1 Chemical Structure| 1354355-91-1

Structure of 1354355-91-1

Chemical Structure| 1354355-91-1

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Product Details of [ 1354355-91-1 ]

CAS No. :1354355-91-1
Formula : C13H15N3
M.W : 213.28
SMILES Code : NCC1=CC(C)=C(C2=CC(C)=NC=C2)N=C1

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Application In Synthesis of [ 1354355-91-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1354355-91-1 ]

[ 1354355-91-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 7113-10-2 ]
  • [ 1354355-91-1 ]
  • N-((2',3-dimethyl-[2,4'-bipyridin]-5-yl)methyl)-2-phenylthiazole-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
44.7% With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; at 20℃; for 2h; To a solution of 1-2 (0.8 g, 3.9 mmol) and REX-P-INT-1 (0.9 g, 4.3 mmol) in DMSO (20 ml) was added N,N-diisopropylethylamine (1.7 mL, 11.7 mmol) and o-(7-azabenzotriazol-1-yl)-N,N,N?,N?-te-tramethyluronium hexafluorophosphate (1.8 g, 4.7 mmol). The reaction mixture was stirred at room temperature for 2 hours and quenched with ice water (50 mL), extracted with EtOAc, washed with brine, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product REX-P-5 (0.7 g, 44.7%). MS m/z [ESI]: 401.1 [M+1]. 1H-NMR (400 MHz, DMSO-d6): delta=9.20 (t, J=6.0 Hz, 1H), 8.51-8.55 (m, 2H), 8.35 (s, 1H), 8.05-8.11 (m, 2H), 7.72 (s, 1H), 7.53-7.57 (m, 3H), 7.40 (s, 1H), 7.34 (d, J=4.8 Hz, 1H), 4.57 (d, J=6 Hz, 2H), 2.53 (s, 3H), 2.35 (s, 3H).
  • 2
  • [ 10250-64-3 ]
  • [ 1354355-91-1 ]
  • N-((2',3-dimethyl-[2,4'-bipyridin]-5-yl)methyl)-1-methyl-3-phenyl-1H-pyrazole-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
64.5% With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; at 20℃; for 2h; To a solution of 1-3 (207.0 mg, 1.0 mmol) and REX-P-INT-1 (260.3 mg, 1.2 mmol) in DMSO (20 mL) was added N,N-diisopropylethylamine (0.5 mL, 3.0 mmol) and o-(7-azabenzotriazol-1-yl)-N,N,N?,N?-tetramethyluronium hexafluorophosphate (452.0 mg, 1.2 mmol). The reaction mixture was stirred at room temperature for 2 hours and quenched with ice water (50 mL), extracted with EtOAc, washed with brine, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product REX-P-9 (256.2 mg, 64.5%). MS m/z [ESI]: 398.2 [M+1]. 1H-NMR (400 MHz, DMSO-d6): delta=8.87 (t, J=6.0 Hz, 1H), 8.53 (d, J=5.2 Hz, 1H), 8.49 (s, 1H), 7.68 (s, 1H), 7.45-7.61 (m, 5H), 7.42 (s, 1H), 7.36 (d, J=4.8 Hz, 1H), 6.80 (s, 1H), 4.487 (d, J=6.0 Hz, 2H), 3.92 (s, 3H), 2.541 (s, 3H), 2.33 (s, 3H).
 

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