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Chemical Structure| 1356016-36-8 Chemical Structure| 1356016-36-8

Structure of 1356016-36-8

Chemical Structure| 1356016-36-8

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Product Details of [ 1356016-36-8 ]

CAS No. :1356016-36-8
Formula : C7H3ClN2O2S
M.W : 214.63
SMILES Code : O=C(C1=CSC2=CN=C(Cl)N=C21)O
MDL No. :MFCD20259395

Safety of [ 1356016-36-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 1356016-36-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1356016-36-8 ]

[ 1356016-36-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2243-82-5 ]
  • [ 1356016-36-8 ]
  • [ 1446510-36-6 ]
YieldReaction ConditionsOperation in experiment
0.105 g With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 2h; Step 1 2-Chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid naphthlen-2-ylamide To a stirred solution of 2-chlorothieno[3,2-d]pyrimidine-7-carboxylic acid (0.050 g, 0.233 mmol) in DMF (2 mL) was added naphthalene-2-amide (0.067 g, 0.466 mmol), DIPEA (0.163 mL, 0.932 mmol), 1-hydroxy-7-azabenzotriazole (0.048 g, 0.349 mmol) and HATU (0.133 g, 0.349 mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with dichloromethane and water. The organic layer was washed with aqueous sodium carbonate, then brine, and then dried over anhydrous Na2SO4, filtered and concentrated in vacuo in vacuo. The residue was dried under high vacuum overnight to give 2-chloro-thieno[3,2-d]pyrimidine-7-carboxylic acid naphthlen-2-ylamide (0.105 g, 0.309 mmol, 133percent) as a brown semi-solid, which was used directly in the next step without further purification. LCMS m/z [M+H]=340
 

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