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Chemical Structure| 1356054-75-5 Chemical Structure| 1356054-75-5

Structure of 1356054-75-5

Chemical Structure| 1356054-75-5

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Product Details of [ 1356054-75-5 ]

CAS No. :1356054-75-5
Formula : C7H8IN3O
M.W : 277.06
SMILES Code : OC1CN(C2=NC=NC=C2I)C1

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Application In Synthesis of [ 1356054-75-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1356054-75-5 ]

[ 1356054-75-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18621-18-6 ]
  • [ 63558-65-6 ]
  • [ 1356054-75-5 ]
YieldReaction ConditionsOperation in experiment
93% With caesium carbonate; In 1,2-dimethoxyethane; at 120℃; for 2h;Inert atmosphere; capped; To a 150 mL pressure reaction bottle under 2 was added 4-chloro-5- iodopyrimidine (884 mg, 3.68 mmol), azetidin-3-ol, HC1 (1.29 g, 11.8 mmol), cesium carbonate (8.40 g, 25.8 mmol), and 1 ,2-dimethoxyethane (19 mL). The reaction mixture was stirred, flushed with argon for 5 min, securely capped and heated at 120C for 2h. The reaction mixture was filtered reaction through small Celite plug by gravity, washed with dichloromethane (125 mL) and the volatiles evaporated in vacuo to give 950 mg (93%) of the title compound as a white solid.
 

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