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Chemical Structure| 1378382-90-1 Chemical Structure| 1378382-90-1

Structure of 1378382-90-1

Chemical Structure| 1378382-90-1

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Product Details of [ 1378382-90-1 ]

CAS No. :1378382-90-1
Formula : C13H20BrIOSi
M.W : 427.19
SMILES Code : C[Si](C(C)(C)C)(OCC1=CC(I)=CC=C1Br)C
MDL No. :MFCD28403060

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Application In Synthesis of [ 1378382-90-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1378382-90-1 ]

[ 1378382-90-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67442-07-3 ]
  • [ 1378382-90-1 ]
  • [ 1378382-92-3 ]
YieldReaction ConditionsOperation in experiment
67% To a solution of (2-bromo-5-iodobenzyloxy)-(teri-butyl)dimethylsilane (8.7 g, 20.3 mmol) in tetrahydrofuran (135 mL) under argon at -20 °C was added z-propylmagnesium chloride - lithium chloride solution (1.3M in THF, 16.4 mL, 21.3 mmol). After stirring at this temperature for thirty minutes, a solution of 2-chloro-N-methoxy-N-methyl acetamide (3.4 g, 24.3 mmol) in tetrahydrofuran (5 mL) was added to the reaction via cannula. The reaction was stirred at -20 °C for one hour and then warmed to room temperature. After one hour at room temperature the reaction was diluted with ethyl acetate and the organics were washed with saturated aqueous NH4CI solution, water and brine. The organic layer was dried (MgS04) and concentrated, and the resulting residue was purified by flash chromatography to yield l -(4-bromo-3-((tert- butyldimethylsilyloxy)methyl)phenyl)-2-chloroethanone (5.1 g, 67percent).
 

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