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Chemical Structure| 13795-73-8 Chemical Structure| 13795-73-8

Structure of 13795-73-8

Chemical Structure| 13795-73-8

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Product Details of [ 13795-73-8 ]

CAS No. :13795-73-8
Formula : C12H23NO4
M.W : 245.32
SMILES Code : O=C(OC(C)(C)C)[C@@H](N)CC(OC(C)(C)C)=O
MDL No. :MFCD08669800

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Application In Synthesis of [ 13795-73-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13795-73-8 ]

[ 13795-73-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13795-73-8 ]
  • [ 1791-13-5 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; at 5 - 10℃; for 0.5h; [ The oil of EXAMPLE 1 above was dissolved in 130 ml of ethyl acetate (EtOAc) and added to a Fisher Porter Bottle (Andrew Glass Co., Vineland, N.J.) containing 22 ml of 5% palladium on activated carbon (Pd/C), 61.81% water (1.99 g, 2.5 wt. %) and ethyl acetate. The resulting solution, which contained Z-Asp(OtBu)2 was kept at room tempera ture, under a hydrogen pressure measured at 60 psi, for three hours. During this time, a hydrogenolysis reaction took place. Afterward, the solution was filtered over Celite (Aldrich, Milwaukee, Wis.) to separate the metal-containing catalyst. The catalyst was rinsed twice with about 30 ml of ethyl acetate for reuse. The filtrate containing L-Asp di-tert butyl amino ester (L-Asp(OtBu)2) was cooled to a temperature of about 5 C to 100 C. Then 18.9 ml (75.6 mmol) of 4M HCl (in dioxane) was added to the filtrate while stirring. The temperature of the filtrate-HCl reaction solution was maintained at a temperature of about 5 C to 10 C. After stirring for about 30 minutes, the mixture was filtered. The wet cake was washed twice, each time with 25 ml of ethyl acetate. The washed wet cake was dried by suction for 30 minutes and then dried in vacuo at a temperature of about 50 C. A white solid obtained was L-Asp di-tert-butyl amino ester hydrochloride salt (L-Asp(OtBu)2.HCl)(15.79 grams), 50% yield from Z-Asp.
 

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