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Chemical Structure| 1380343-09-8 Chemical Structure| 1380343-09-8

Structure of 1380343-09-8

Chemical Structure| 1380343-09-8

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Product Details of [ 1380343-09-8 ]

CAS No. :1380343-09-8
Formula : C10H13ClN4
M.W : 224.69
SMILES Code : CCCNC1=NC(Cl)=C2C(N(C)C=C2)=N1

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1380343-09-8 ]

[ 1380343-09-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1380343-09-8 ]
  • [ 5382-17-2 ]
  • [ 1380343-16-7 ]
YieldReaction ConditionsOperation in experiment
75% With potassium carbonate; In butan-1-ol; at 130℃; for 16.0h;autoclave; 2-(;j-Propyl)aniino-4-chloro-7-methyl-pyrrolo[2,3-d]pyrimidine (CXXIV) (1.6 g, 7.1 mmol) was added to n-butanol (10 mL) followed by potassium carbonate (4.9 g, 35.5 mmol) and <strong>[5382-17-2]piperidin-4-ol hydrochloride</strong> (632 mg, 10.7 mmol). The mixture was stirred in an autoclave equipped with a stirrer at 130 °C for 16 h. After cooling to room temperature, water was added (20 mL), and the mixture was extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water and then with a brine solution, and dried over anhydrous Na2S0 . The solvents were removed in vacuo and the residue was purified by flash column chromatography (pet ether/EtOAc=3/l) to yield 2-(/i-propyl)amino-4-(4-hydroxypiperidin-1-yl)-7- methyl-pyrrolo[2,3-d]pyrimidine (1.2 g, 75percent) as a yellow solid. LCMS (ESI) m/z = 290 (M+H)+.
 

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