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Chemical Structure| 1383740-05-3 Chemical Structure| 1383740-05-3

Structure of 1383740-05-3

Chemical Structure| 1383740-05-3

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Product Details of [ 1383740-05-3 ]

CAS No. :1383740-05-3
Formula : C10H8ClNO3S
M.W : 257.69
SMILES Code : O=C(C1=CC(OC)=C2N=C(Cl)SC2=C1)OC

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Application In Synthesis of [ 1383740-05-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383740-05-3 ]

[ 1383740-05-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1383740-05-3 ]
  • [ 94242-85-0 ]
  • methyl 2-methyl-4-methoxy-1,3-benzothiazole-6-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
43% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 100℃; for 3h;Inert atmosphere; To a solution of methyl 2-chloro-4-methoxy-l,3-benzothiazole-6-carboxylate (514 mg, 1.99 mmol) in dioxane (7 mL) was added pentamethyl-l,3,2-dioxaborolane (426 mg, 3.0 mmol), Pd(dppf)Cl2(146 mg, 0.20 mmol),sodium carbonate (636 mg, 5.94 mmol) and water (2 mL). The resulting solution was stirred for 3 h at 100°C under N2atmosphere. The solids were filtered out and the resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (21 :79). This resulted in 200 mg (43percent) of the title compound as a yellow solid. LC-MS (ESI, m/z): [M+H]+= 238.1.
 

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