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Chemical Structure| 1383973-78-1 Chemical Structure| 1383973-78-1

Structure of 1383973-78-1

Chemical Structure| 1383973-78-1

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Product Details of [ 1383973-78-1 ]

CAS No. :1383973-78-1
Formula : C10H17NO2
M.W : 183.25
SMILES Code : O=C(C1(C2)CCCC2(N)CC1)OC

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Application In Synthesis of [ 1383973-78-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1383973-78-1 ]

[ 1383973-78-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 62638-06-6 ]
  • [ 1383973-78-1 ]
  • 2
  • [ 5521-61-9 ]
  • [ 1383973-78-1 ]
  • [ 1383973-79-2 ]
YieldReaction ConditionsOperation in experiment
79% With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 18 - 25℃; Step 2: methyl 5-(6-methylpyrazine-2-carboxamido)bicyclo[3.2.11 octane-l-carboxylateTo a solution of methyl 5-aminobicyclo[3.2.1 ]octane- l -carboxylate (0.98 g, 5.36 mmol) and <strong>[5521-61-9]6-methylpyrazine-2-carboxylic acid</strong> (0.89 g, 6.45 mmol) in DCM (30 mL) and TEA (2 mL) was added PyBOP (3.35 g, 6.44 mmol). After stirring at room temperature overnight, water (30 mL) was added and the mixture was extracted with DCM (3 x 50 mL). The combined organic layer was washed with Sat. NaHC0 (50 mL) and brine (50 mL), dried over a2S04 and concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate: 1/1 ) to afford 1 .28 g (79percent) of methyl 5-(6-methylpyrazine-2-carboxamido)bicyclo[3.2.1]octane-l -carboxylate as an off- white solid. ESI-MS m/z: 304 (M+H)+.
 

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