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Chemical Structure| 1386980-73-9 Chemical Structure| 1386980-73-9

Structure of 1386980-73-9

Chemical Structure| 1386980-73-9

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Product Details of [ 1386980-73-9 ]

CAS No. :1386980-73-9
Formula : C9H7N3O4
M.W : 221.17
SMILES Code : O=C(C1=CC2=CN=C(OC)N=C2NC1=O)O
MDL No. :MFCD22573969

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Application In Synthesis of [ 1386980-73-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1386980-73-9 ]

[ 1386980-73-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1386980-73-9 ]
  • [ 369-26-6 ]
  • [ 1386979-42-5 ]
YieldReaction ConditionsOperation in experiment
53.7% With triethylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 20h; Triethylamine (61 mg, 0.60 mmol) was added to a mixture of crude 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid (110 mg, 0.5 mmol) (from Example 18 supra) and HATU (0.23 g, 0.6 mmol) (Aldrich) in DMF (5.0 mL) at room temperature. The resulting mixture was stirred until clear solution was obtained (light brown). Methyl 3-amino-4-fluorobenzoate (0.110 g, 0.6 mmol) (Bionet) was added. The mixture was stirred for another 20 hours. Precipitate was formed. Water (50 mL), aqueous saturated sodium bicarbonate solution (10 mL), and ethyl acetate (30 mL) were added. After thorough mixing, pale yellow precipitate was collected by filtration, washed with water and ethyl acetate and dried in vacuum oven. Residue was recrystallized from DMF-ethyl acetate-hexanes to give 4-fluoro-3-[(2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoic acid methyl ester as pale yellow needles. (Yield 0.10 g, 53.7percent).LR-LC/MS (APCi+) m/z [M+H]+ 373.
 

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