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Chemical Structure| 1392497-89-0 Chemical Structure| 1392497-89-0

Structure of 1392497-89-0

Chemical Structure| 1392497-89-0

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Product Details of [ 1392497-89-0 ]

CAS No. :1392497-89-0
Formula : C12H16O4
M.W : 224.25
SMILES Code : OC/C=C/C1=CC(OC)=C(OC)C=C1OC
MDL No. :MFCD21852713

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Application In Synthesis of [ 1392497-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1392497-89-0 ]

[ 1392497-89-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 18944-77-9 ]
  • [ 1392497-89-0 ]
  • (E)-3-(2,4,5-trimethoxyphenyl)allyl (E)-3-(2-fluorophenyl)acrylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
72.9% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃;Inert atmosphere; General procedure: A mixture of the compound 3 or 4 (5mmol), cinnamic acid derivatives (6mmol), and DMAP (1mmol) in DCM (15mL) was stirred for 10minat room temperature. Successively, EDCI (6-10mmol) were added quickly in one portion. The reaction mixture was continually stirred at room temperature for 10-18h under nitrogen and monitored by TLC. Then the clear solution treated with an aqueous saturated NaHCO3 solution containing ice (60mL) for 5min. The aqueous reaction mixture was extracted with DCM (3×20mL). The combined extracts were dried with dry Na2SO4 and concentrated in vacuo. The crude compound was purified by flash chromatography (SiO2; 100:0-50:50-0:100 hexanes/DCM, v/v). The final esters were obtained as solid substances after concentration of organic solvents under reduced pressure.
 

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