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Chemical Structure| 1393477-26-3 Chemical Structure| 1393477-26-3

Structure of 1393477-26-3

Chemical Structure| 1393477-26-3

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Product Details of [ 1393477-26-3 ]

CAS No. :1393477-26-3
Formula : C8H10BNO2
M.W : 162.98
SMILES Code : NC[C@H]1OB(O)C2=CC=CC=C12

Safety of [ 1393477-26-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P264-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P501
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 1393477-26-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1393477-26-3 ]

[ 1393477-26-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1393477-26-3 ]
  • [ 1397-89-3 ]
  • C55H81BN2O18 [ No CAS ]
YieldReaction ConditionsOperation in experiment
10% With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dimethyl sulfoxide; for 5.5h;pH 7.5 - 8; (S)-3-(Aminomethyl)benzo[c][1,2]oxaborol-1(3)-ole (202 mg, 0.971 mmol)was added to a solution of AmB (1) (300 mg, 0.325 mmol) in DMSO (2 ml),pH of reaction mixture was kept at 7.5-8 by adding a solution of Et3N inDMSO. PyBOP (270 mg, 0.519 mmol) was added to the reaction mixtureportionwise during 1.5 h. The reaction mixture was stirred for 4 h, and thenether was added. The mixture was stirred vigorously, then the ether layer wasremoved and the procedure was repeated several times until a viscous oil wasformed. Acetone was added to the oil; the forming precipitate was filtered off,washed with acetone and dried in vacuum. The progress of the reactions, thecomponents of the column and the purity of final compounds were monitoredby TLC in the system CHCl3CHCl3MeOHNH4OH (4:1:0.1) and HPLCanalysis. The crude amide was purified by column chromatography on silicagel. The amide was dissolved in DMF (2 ml) and put on a column preequilibratedwith CHCl3. The elution was carried out with CHCl3 (150 ml) andthen with a mixture CHCl3MeOHNH4OH (4:1:0.1). Fractions containingthe target compound were combined and evaporated to a small volume. Theaddition of acetone to the solution gave the precipitate that was fostered off anddried. Yield: 30 mg (10%).
 

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