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Chemical Structure| 1400661-81-5 Chemical Structure| 1400661-81-5

Structure of 1400661-81-5

Chemical Structure| 1400661-81-5

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Product Details of [ 1400661-81-5 ]

CAS No. :1400661-81-5
Formula : C8H5F3O4S
M.W : 254.18
SMILES Code : O=C(C1=CC(C(F)(F)F)=C(C(OC)=O)S1)O
MDL No. :MFCD22689991

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Application In Synthesis of [ 1400661-81-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1400661-81-5 ]

[ 1400661-81-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1400661-81-5 ]
  • [ 3468-18-6 ]
  • [ 1400661-82-6 ]
YieldReaction ConditionsOperation in experiment
31% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20℃; for 3h; Preparation of 5-[(1H-Indol-4-ylmethyl)-carbamoyl]-3-trifluoromethyl-thiophene-2-carboxylic acid methyl ester To a solution of 3-Trifluoromethyl-thiophene-2,5-dicarboxylic acid 2-methyl ester (570 mg, 2.24 mmol) in anhydrous DMF (10 mL) was added triethylamine (1.25 mL, 8.96 mmol), EDC (520 mg, 2.69 mmol), HOBT (360 mg, 2.69 mmol), and C-(1H-Indol-4-yl)-methylamine (390 mg, 2.69 mmol). The mixture was stirred at room temperature 3 h, then quenched by pouring into EtOAc. The organic layer was washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by flash chromatography with 0-70% EtOAc in hexane to afford the desired product (0.27 g, 31% yield).
 

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