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Chemical Structure| 140174-48-7 Chemical Structure| 140174-48-7

Structure of 140174-48-7

Chemical Structure| 140174-48-7

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Product Details of [ 140174-48-7 ]

CAS No. :140174-48-7
Formula : C6H9N3O3S
M.W : 203.22
SMILES Code : O=S(N1C=C(C=O)N=C1)(N(C)C)=O
MDL No. :MFCD09800947

Safety of [ 140174-48-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 140174-48-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 140174-48-7 ]

[ 140174-48-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 426219-35-4 ]
  • [ 140174-48-7 ]
  • [ 1416216-42-6 ]
YieldReaction ConditionsOperation in experiment
Example 12Under a nitrogen atmosphere, .6-bromo-N-methyl-2- naphthamide (10.0 g, 38 mmol) was added to tetrahydrofuran (250 mL) , and then 2.0 mol/L isopropylmagnesium chloride tetrahydrofuran solution (19 mL) was added dropwise thereto at room temperature. The obtained reaction mixture was cooled to -20C, 1.6 mol/L n-butyllithium hexane solution (40 mL) was added dropwise to the reaction mixture, and the mixture was stirred at the same temperature for 2 hr. To the obtained reaction mixture was added dropwise a solution of 1-N,N- dimethylaminosulfonyl-4-formyl-lH-imidazole (11.6 g, 57 mmol) in tetrahydrofuran (200 mL) at -20C, and the mixture was stirred at the same temperature for 2 hr. The obtained reaction mixture was allowed to warm to 0C, and stirred for 1 hr, and 20w/v% aqueous ammonium chloride solution (150 mL) was added dropwise to the reaction mixture. The reaction mixture was separated to the organic layer and aqueous layer, and the obtained organic layer was concentrated to the volume of about 90 mL under reduced pressure. To the obtained residue was added tetrahydrofuran (140 mL) , and the obtained reaction mixture was concentrated to the volume of about 80 mL under reduced pressure. To the obtained residue was added ethyl acetate (250 mL) , and the mixture was concentrated to the volume of about 80 mL under reduced pressure. These operations were repeated three times. To the obtained residue was added ethyl acetate to adjust the volume to about 200 mL to give a ethyl acetate solution containing 6- [hydroxy ( 1-N, N- dimethylaminosulfonyl-lH-imidazol-4-yl) methyl] -N-methyl-2- naphthamide .The NMR data of the obtained 6- [hydroxy ( 1-N, N- dimethylaminosulfonyl-lH-imidazol-4-yl) methyl] -N-methyl-2- naphthamide was shown below.XH NMR (500 MHz, DMSO-d6) delta 2.76-2.88 (m, 9H) , 5.82 (s, lH) , 6.08 (s, 1H) , 7.37-7.43 (m, 1H) , 7.61 (dd, J = 8.5, 1.58 Hz, 1H), 7.84-8.02 (m, 4H) , 8.07 (d, J = 1.3 Hz, 1H) , 8.39 (s, 1H) , 8.59 (d, J = 4.1Hz, 1H) ; HRMS (ESI) m/z Calcd for aC18H21 4O4S [m+H] + : 389.1205, Found: 389.1273
 

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