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Chemical Structure| 141454-61-7 Chemical Structure| 141454-61-7

Structure of 141454-61-7

Chemical Structure| 141454-61-7

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Product Details of [ 141454-61-7 ]

CAS No. :141454-61-7
Formula : C7H6BrClN2O
M.W : 249.49
SMILES Code : O=C(NC1=NC=C(Br)C=C1)CCl
MDL No. :MFCD00461174

Safety of [ 141454-61-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H315-H318-H335
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 141454-61-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 141454-61-7 ]

[ 141454-61-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 117810-52-3 ]
  • [ 141454-61-7 ]
  • [ 1226595-20-5 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60℃; Intermediate of Formula VI; N-(5-Bromo-pyridin-2-yl)-2-(6-oxo-hexahydro-pyrrolo[ 1 ,2-a]pyrazin-2-yl)-acetamide: N-(5- Bromo-2-pyridinyl)-2-chloroacetamide (253mg, l.Olmmol) was dissolved in DMF (5mL) at room temperature. Hexahydro-pyrrolo[l,2-a]pyrazin-6-one (142mg, l.Olmmol) (Christensen et. al. WO2008046882) was added followed by potassium carbonate (350mg, 2.53mmol). The reaction mixture was stirred overnight at 6O0C. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (25mL), and transferred to a separatory funnel. The reaction mixture was washed with water (3 X 25mL). The organic phase was dried over magnesium sulfate, filtered through a pad of silica, then concentrated. The product was isolated by preparative thin layer chromatography eluting with 98/2 methylene chloride/methanol to afford 95mg of the title compound. 1H NMR (400 MHz, CDCl3) δ 9.47 (br s, IH), 8.34 (d, J = 2.3 Hz, IH), 8.18 (d, J = 9.0 Hz, IH), 7.82 (dd, J = 9.0 Hz, J = 2.3 Hz, IH), 4.13-4.05 (m, 2H), 3.83-3.74 (m, IH), 3.22 (dd, J = 15.4 Hz, J = 4.8 Hz, 2H), 3.07-2.96 (m, 2H), 2.91-2.86 (m, 2H), 2.48-2.39 (m, 2H), 2.33-2.17 (m, 2H), 1.68-1.57 (m, IH). ESI-MS m/z: 354.9 (M + H)+.
 

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