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Chemical Structure| 1417334-55-4 Chemical Structure| 1417334-55-4

Structure of 1417334-55-4

Chemical Structure| 1417334-55-4

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Product Details of [ 1417334-55-4 ]

CAS No. :1417334-55-4
Formula : C8H4BrF3N2
M.W : 265.03
SMILES Code : FC(C1=CC(Br)=CN2C1=NC=C2)(F)F
MDL No. :MFCD22577291
InChI Key :JZVYHKXYTNZPJN-UHFFFAOYSA-N
Pubchem ID :75365455

Safety of [ 1417334-55-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1417334-55-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1417334-55-4 ]

[ 1417334-55-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1417334-55-4 ]
  • [ 628692-15-9 ]
  • [ 1611002-09-5 ]
YieldReaction ConditionsOperation in experiment
66.2% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate; In N,N-dimethyl-formamide; at 120℃; for 2h;Inert atmosphere; The compound of example 172 (3 g, 11.32 mmol) was treated with (2- methoxypyrimidin-5-yl)boronic acid (2.091 g, 13.58 mmol) in the presence of [1,1'- bis(diphenylphosphino)-ferrocene] dichloropalladium(ll) complex with dichloromethane (0.159 g, 0.226 mmol) and sodium carbonate (2.347 g, 16.98 mmol) in dry dimethylformamide (10 mL) according to the procedure for the preparation of the compound of example 2 to afford the title compound. Yield: 2.23 g (66.2 percent); 1H NMR (DMSO-de, 300 MHz): delta 3.98 (s, 3H, OCH3), 7.76 (d, 1H, J =0.9 Hz, Ar), 8.07 (s, 1H, Ar), 8.14 (d, 1H, J =0.9 Hz, Ar), 9.02 (s, 2H, Ar), 9.25 (s, 1H, Ar); MS (ES+): m/e 295.4 (M+1).
 

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