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Chemical Structure| 1417636-85-1 Chemical Structure| 1417636-85-1

Structure of 1417636-85-1

Chemical Structure| 1417636-85-1

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Product Details of [ 1417636-85-1 ]

CAS No. :1417636-85-1
Formula : C8H7ClN2O2
M.W : 198.61
SMILES Code : O=C(C1=CC2=CN=CN2C=C1)O.[H]Cl
MDL No. :MFCD26593821

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Application In Synthesis of [ 1417636-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1417636-85-1 ]

[ 1417636-85-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1417636-85-1 ]
  • [ 94341-56-7 ]
  • [ 1454284-71-9 ]
YieldReaction ConditionsOperation in experiment
30% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; A solution of imidazo[1,5-a]pyridine-7-carboxylic acid hydrochloride (50 mg, 0.25 mmol, 1.00 equiv), <strong>[94341-56-7][4-(benzenesulfonyl)phenyl]methanamine</strong> (120 mg, 0.49 mmol, 1.57 equiv), HOBt (100 mg, 0.74 mmol, 2.40 equiv), EDCI (150 mg, 0.78 mmol, 3.13 equiv), and diisopropylethylamine (1 mL) in DMF (3 mL) was stirred overnight at rt. The resulting mixture was concentrated under vacuum and the residue was purified on a silica gel column with ethyl acetate/hexane (4:1) to give 0.03 g (30%) of the title compound as a light yellow solid. LC/MS (Method F, ESI): RT = 1.34 min, m z = 392.1 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta 9.1 3 (t, J = 5.6 Hz, 1H), 8.48 (s, 1 H), 8.36 (d, J = 7.2 Etaz 1Eta), 8.1 8 (s, 1 H), 7.95-7.92 (m, 4H), 7.72 -7.54 (m, 6H), 7.05 (dd, J = 7.4 Hz, J = 1.4 Hz, 1 H), 4.53 (d, J = 5.6 Hz, 2H).
 

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