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Chemical Structure| 1417656-45-1 Chemical Structure| 1417656-45-1

Structure of 1417656-45-1

Chemical Structure| 1417656-45-1

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Product Details of [ 1417656-45-1 ]

CAS No. :1417656-45-1
Formula : C8H12N2
M.W : 136.19
SMILES Code : CC(N)C1=NC=C(C)C=C1

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Application In Synthesis of [ 1417656-45-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1417656-45-1 ]

[ 1417656-45-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 23020-15-7 ]
  • [ 1417656-45-1 ]
  • [ 1417655-74-3 ]
YieldReaction ConditionsOperation in experiment
16% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; ethyl acetate; General procedure: (1S,2S)-2-Phenyl-cyclopropanecarboxylic acid [(S)-1-(5-methyl-pyridin-2-yl)ethyl]-amide N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (0.709 g, 3.70 mmol) and 1-hydroxybenzotriazole (0.667 g, 4.93 mmol) were added to a stirred mixture of IM46 (0.60 g, 3.70 mmol) and commercially available (S)-1-(5-methyl-pyridin-2-yl)-ethylamine hydrochloride (Supplier Netchem Inc., Catalog No 528193) (0.426 g, 2.47 mmol) and N,N-diisopropylethylamine (0.859 ml, 4.93 mmol) in THF (25 ml). The solution was stirred at rt overnight. Water was added and the mixture was extracted with EtOAc (3*80 ml). The combined organic phases were washed with brine, dried over MgSO4, filtered and the solvent was evaporated of in vac. The crude product was purified by silica gel chromatography (EtOAc in heptanes 1:1). Yield of Compound 2: 110 mg (16%). LC-MS (m/z) 281.1 (MH+), tR=0.91 min (method A).
 

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