23020-15-7|(1S,2S)-2-Phenylcyclopropanecarboxylic acid| Ambeed

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Quality Control of [ 23020-15-7 ] Purity: 98% SDS Specification

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Product Details of [ 23020-15-7 ]

CAS No. :	23020-15-7
Formula :	C₁₀H₁₀O₂
M.W :	162.19
SMILES Code :	O=C([C@@H]1[C@@H](C2=CC=CC=C2)C1)O
MDL No. :	MFCD12195831
InChI Key :	AHDDRJBFJBDEPW-BDAKNGLRSA-N
Pubchem ID :	778517

Safety of [ 23020-15-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 23020-15-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 23020-15-7 ]

[ 23020-15-7 ] Synthesis Path-Downstream 1~35

1
[ 908094-01-9 ]
[ 23020-15-7 ]
(1S,2S)-2-phenylcyclopropanecarboxylic acid methyl ester [ No CAS ]

References: [1]Helvetica Chimica Acta,1986,vol. 69,p. 1936 - 1958.
[2]Journal of Organic Chemistry,1978,vol. 43,p. 4447 - 4452.
[3]Tetrahedron,1970,vol. 26,p. 1675 - 1684.
[4]Organic and Biomolecular Chemistry,2006,vol. 4,p. 2777 - 2784.
[5]Bioorganic and Medicinal Chemistry,2009,vol. 17,p. 2388 - 2399.

2
[ 23020-15-7 ]
[ 29667-50-3 ]

References: [1]Tetrahedron,1970,vol. 26,p. 1675 - 1684.

3
[ 23020-15-7 ]
(+)-trans-2-Phenylcyclopropyliodid [ No CAS ]

References: [1]Tetrahedron,1970,vol. 26,p. 1675 - 1684.

4
[ 23020-15-7 ]
[ 110659-58-0 ]

References: [1]Bulletin of the Chemical Society of Japan,1981,vol. 54,p. 2151 - 2160.
[2]Journal of Organic Chemistry,1994,vol. 59,p. 7401 - 7409.
[3]Helvetica Chimica Acta,1986,vol. 69,p. 1936 - 1958.
[4]Patent: CN105566262,2016,A .

5
ethyl (S,S)-2-phenylcyclopropane-1-carboxylate [ No CAS ]
[ 23020-15-7 ]

References: [1]Helvetica Chimica Acta,1986,vol. 69,p. 1936 - 1958.
[2]Angewandte Chemie,1992,vol. 104,p. 439 - 441.
[3]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.
[4]Journal of Medicinal Chemistry,2016,vol. 59,p. 1501 - 1517.
[5]Angewandte Chemie - International Edition,2016,vol. 55,p. 16110 - 16114.
Angew. Chem.,2016,vol. 128,p. 16344 - 16348.

6
[ 939-90-2 ]
[ 23020-15-7 ]

Yield	Reaction Conditions	Operation in experiment
	With ChiralpakAD 5 u; In ethanol; at 35℃; under 75007.5 Torr;Supercritical conditions; Resolution of racemate;	Preparative supercritical fluid chromatography (SFC) was performed on a Berger Multigram II operating at 50 mL/min at 35 C. and 100 bar backpressure using stacked injections. The column was a ChiralpakAD 5 u, 250×21 mm. The eluent was CO2 (70%) and ethanol (30%).

References: [1]Bulletin of the Chemical Society of Japan,1981,vol. 54,p. 2151 - 2160.
[2]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.
[3]Patent: US2013/12530,2013,A1 .Location in patent: Paragraph 0165.
[4]Patent: WO2014/19023,2014,A1 .
[5]ChemMedChem,2016,p. 1904 - 1914.

7
[ 23020-15-7 ]
[ 222632-77-1 ]
((1S,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine-1-carbonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1999,vol. 9,p. 437 - 442.

8
[ 23020-15-7 ]
[ 3721-28-6 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 6501 - 6505.
[2]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.

9
(+/-)-trans-2-phenylcyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 928054-81-3 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 6501 - 6505.
[2]Tetrahedron Letters,2000,vol. 41,p. 6501 - 6505.

10
(+/-)-trans-2-phenylcyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]Tetrahedron Letters,2000,vol. 41,p. 6501 - 6505.
[2]Advanced Synthesis and Catalysis,2003,vol. 345,p. 695 - 698.

11
[ 23020-15-7 ]
[ 1013-76-9 ]
[ 307952-37-0 ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

12
[ 23020-15-7 ]
[ 1013-78-1 ]
[ 307952-30-3 ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

13
[ 131899-86-0 ]
[ 23020-15-7 ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

14
rac-(1R,2R)-2-phenylcyclopropanecarboxamide [ No CAS ]
[ 23020-15-7 ]
[ 928054-81-3 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]Tetrahedron Asymmetry,2004,vol. 15,p. 347 - 354.
[2]New Journal of Chemistry,2002,vol. 26,p. 1575 - 1583.

15
2-phenyl-cyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]New Journal of Chemistry,2002,vol. 26,p. 1575 - 1583.
[2]New Journal of Chemistry,2002,vol. 26,p. 1575 - 1583.

16
(1S)-1-formyl-2-phenylcyclopropane [ No CAS ]
[ 23020-15-7 ]
[ 23020-18-0 ]

References: [1]Journal of Organic Chemistry,2003,vol. 68,p. 9255 - 9262.

17
(+/-)-trans-2-phenylcyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 58641-87-5 ]
[ 3471-10-1 ]
trans-2-phenylcyclopropanecarbonitrile [ No CAS ]

References: [1]Tetrahedron Asymmetry,2004,vol. 15,p. 347 - 354.

18
[ 23020-15-7 ]
meso-1,2-diphenyl-1,2-diaminoethane [ No CAS ]
(1S,2S)-2-Phenyl-cyclopropanecarboxylic acid (2-amino-1,2-diphenyl-ethyl)-amide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 435 - 438.

19
[ 23020-15-7 ]
[ 473252-82-3 ]
(4-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidin-1-yl)-((1S,2S)-2-phenyl-cyclopropyl)-methanone [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1766 - 1772.

20
[ 939-90-2 ]
[ 23020-15-7 ]
[ 3471-10-1 ]

Yield	Reaction Conditions	Operation in experiment
	Resolution of racemate;	±trans-2-phenylcyclopropanecarboxylic acid was separated into constituent enantiomers (Intermediate Y and Z) using chiral SFC. Intermediate Y: 1HNMR (300 MHz, CDC13) δ 1HNMR (300 MHz, CDC13) δ 7.35-7.09 (m, 5H), 2.61 (ddd, 1H), 1.91 (dq, 1H), 1.67 (q, 1H), 1.42 (dq, 1H). ESIMS m/z [M-H]+ 161.2. [a]D24 4 -259.546 (c 0.119, MeOH). Absolute stereochemistry assigned by comparison with literature (JMC 2000, p3923; JMC 2011, p957). Intermediate Z: 1HNMR (300 MHz, CDC13) δ 7.35-7.09 (m, 5H), 2.61 (ddd, 1H), 1.91 (dq, J = 4.8, 3.9, 1H), 1.67 (q, 1H), 1.42 (dq, 1H). ESIMS m/z [M-H]+ 161.2. [a]D245 +249.261 (c 0.102, MeOH). Absolute stereochemistry assigned by comparison with literature (JMC 2000, p3923; JMC 2011, p957).

References: [1]Journal of Organic Chemistry,2005,vol. 70,p. 5291 - 5301.
[2]Patent: WO2015/191799,2015,A1 .Location in patent: Page/Page column 48.

21
(+/-)-trans-2-phenylcyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]New Journal of Chemistry,2002,vol. 26,p. 1575 - 1583.

22
(+/-)-trans-2-phenylcyclopropanecarbonitrile [ No CAS ]
[ 23020-15-7 ]
[ 928054-81-3 ]
[ 58641-87-5 ]
[ 3471-10-1 ]

References: [1]New Journal of Chemistry,2002,vol. 26,p. 1575 - 1583.

23
[ 23020-15-7 ]
trans-(S,S)-4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-1-(2-phenylcyclopropylmethyl)piperidine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2006,vol. 49,p. 1766 - 1772.

24
[ 23020-15-7 ]
4,5-Diphenyl-2-((1S,2S)-2-phenyl-cyclopropyl)-4,5-dihydro-1H-imidazole [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 435 - 438.

25
[ 23020-15-7 ]
(1S,2S)-trans-1-[(2-phenylcyclopropyl)methyl]-4-(2,4-dimethylphenyl)piperazine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

26
[ 23020-15-7 ]
(1S,2S)-trans-1-[(2-phenylcyclopropyl)methyl]-4-(2,4-dichlorophenyl)piperazine [ No CAS ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

27
(1SR,2SR)-2-phenylcyclopropanecarbonyl chloride [ No CAS ]
[ 23020-15-7 ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.
[2]Patent: WO2014/19023,2014,A1 .

28
(1R,2R)-2-Phenyl-cyclopropanecarboxylic acid ((R)-1-phenyl-ethyl)-amide [ No CAS ]
[ 23020-15-7 ]

References: [1]Journal of Medicinal Chemistry,2000,vol. 43,p. 3923 - 3932.

29
[ 23020-15-7 ]
(1R,2S)-1-amino-2-phenylcyclopropane [ No CAS ]

References: [1]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.
[2]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.
[3]Angewandte Chemie - International Edition,2016,vol. 55,p. 16110 - 16114.
Angew. Chem.,2016,vol. 128,p. 16344 - 16348.

30
[ 23020-15-7 ]
[ 185256-47-7 ]

References: [1]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.
[2]Tetrahedron Asymmetry,1996,vol. 7,p. 3505 - 3512.

31
[ 23020-15-7 ]
(1S,2S)-2-phenylcyclopropane-1-carbaldehyde [ No CAS ]

References: [1]Journal of Organic Chemistry,1994,vol. 59,p. 7401 - 7409.

32
[ 23020-15-7 ]
(1R,2S)-1-(1-propenyl)-2-phenylcyclopropane [ No CAS ]

References: [1]Journal of Organic Chemistry,1994,vol. 59,p. 7401 - 7409.

33
[ 23020-15-7 ]
(+)-trans-1-(o-Methoxycarbonylphenyl)-2-phenylcyclopropan [ No CAS ]

References: [1]Tetrahedron,1970,vol. 26,p. 1675 - 1684.

34
[ 928055-00-9 ]
[ 23020-15-7 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid; water; In 1,4-dioxane; at 100℃; for 24h;	i) trans-(+)-2-Phenyl-cyclopropanecarboxylic acid; A solution of fcans-(+)-2-phenyl-cyclopropanecarboxylic acid (2-hydroxy-1-phenyl- ethyl)-amide (150 mg, 0.534 mmol) in dioxane (5 mL) was added to 3N H2SO4 (5 mL). The mixture was stirred at 100 C for 24 h and then poured into water and extracted with CH2CI2 (x3). The combined organic phases were dried over MgSO4, EPO <DP n="129"/>filtered and concentrated. and all volatiles were removed under vacuum. The crude residue was purified by silica gel column chromatography using a mixture of EtOAc/hexane (1 :2) as an eluent to afford the title compound as colorless solid (73 mg, 84%). 1H NMR (CDCI3): δ (ppm) 10.3 (br. S, 1 H), 7.34-7.22 (m, 3 H), 7.14 (d, 2 H1 J = 7.0 Hz), 2.64 (m, 1 H), 1.93 (m, 1 H), 1.70 (m, 1 H), 1.44 (m, 1 H). 13C NMR (CDCI3): δ (ppm) 180.2, 139.9, 128.9 (2), 127.1 , 126.7 (2), 27.5, 24.4, 17.9. (+)-CO2H, [α]D +374, c 0.55, CHCI3.

References: [1]ChemMedChem,2016,p. 1904 - 1914.
[2]Journal of Medicinal Chemistry,2009,vol. 52,p. 1885 - 1902.
[3]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 127-128.

35
[ 23020-15-7 ]
[ 78738-39-3 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride;N,N-dimethyl-formamide; In toluene; at 80℃; for 2.5h;	ii) trans-(+)-(2-Phenyl-cyclopropyl)-methylamine hydrochloride; To a solution of /ra/7s-(+)~2-phenyl-cyclopropanecarboxylic acid (60 mg, 0.37 mmol) in toluene (3 ml_) were added dropwise several drops of dimethylformamide and thionyl chloride (0.403 ml_, 5.55 mmol). After stirring at 80 C for 2.5 h, the reaction mixture was concentrated under vacuum. The resulting residue was dissolved in toluene (2 ml_) again, and the solution was added to liquid ammonia (ca. 10 ml_) at - 78 C. After stirring at -78 C for 30 min and then at room temperature for 30 min, CH2CI2 (10 ml) was added to the mixture at -78 C and the resulting mixture was stirred at room temperature overnight. After addition of EtOAc, the mixture was washed with satd. aqueous NH4CI (x2), dried over Na2SO4 and all volatiles were removed under vacuum. The corresponding amide was isolated as pearl yellow powders and further purified by recrystallization from hexane/EtOAc (45 mg).
	With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20℃; for 0.75h;	To a solution of (l S,2S)-2-phenyl-cyclopropanecarboxylic acid ( 170 mg, 1.05 mmol) in dichloromethane ( 10 ml ) was added oxallyl dichloride ( 145 mg, 1.2 mmol) followed by a few drops of N, N-dimethylformamide at RT. The reaction mixture was stirred at RT for 45 mins before it was concentrated down and dissolved in dichloromethane (1.5 ml). The solution was added slowly to a solution of (S)-l- (4-bromo-phenyl)-propylamine (250 mg, l.Ommol, HC1 salt) and triethylamine (222 mg, 2.2 mmol) in dichloromethane (10 ml) at 0 C. The resulting reaction mixture was stirred at RT for 1.5h. Water was added and the aqueous layer was extracted by dichloromethane. Organic layer was dried by magnesium sulfate and concentrated. The residue was purified via column chromatography on silica gel to afford (1 S,2S)- 2-phenyl-cyclopropanecarboxylic acid [(S)-l-(4-bromo-phenyl)-propyl]-amide (330 mg, 92%). XH NMR (400 MHz, CHLOROF ORM-d) δ ppm 7.37 (d, J=8.6 Hz, 2 H), 7.15 - 7.23 (m, 2 H), 7.11 (d, J=7.3 Hz, 1 H), 7.08 (d, J=8.3 Hz, 2 H), 6.98 (d, J=7.3 Hz, 2 H), 5.75 (d, J=7.6 Hz, 1 H), 4.77 (q, J=7.5 Hz, 1 H), 2.31 - 2.41 (m, 1 H), 1.65 - 1.81 (m, 2 H), 1.48 - 1.59 (m, 2 H), 1.12 - 1.23 (m, 1 H), 0.82 (t, J=7.4 Hz, 3 H); LRMS ( ESI) (M + 1) = 360.04. Molecular Formula =Ci9H20BrNO.
	With oxalyl dichloride; In dichloromethane; at 20℃; for 2.5h;	In a dry 100 ml round-bottomed flask was added oxalyl chloride (2.0 ml, 23 mmol) to 8B (0.25 g, 1.5 mmol) in CH2Cl2 at room temperature to give a yellow solution. In 2.5 hours, the reaction was complete. The crude mixture was concentrated in vacuo and residual <n="164"/>PATENT ASKl -5001 -WOTFA was removed azeotropically with toluene 3 times to give the desired product (lS,2S)-2- phenylcyclopropanecarbonyl chloride (8B-1), which was used in the next step without further purification.

References: [1]Patent: WO2007/25144,2007,A1 .Location in patent: Page/Page column 128.
[2]Journal of Medicinal Chemistry,2009,vol. 52,p. 1885 - 1902.
[3]Patent: WO2011/44195,2011,A1 .Location in patent: Page/Page column 26.
[4]Organic Letters,2013,vol. 15,p. 1350 - 1353.
[5]Patent: WO2009/123986,2009,A1 .Location in patent: Page/Page column 162-163.
[6]Journal of the American Chemical Society,2018,vol. 140,p. 15596 - 15600.

Historical Records

Technical Information

• Arndt-Eistert Homologation • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • Halogenation • Heat of Combustion • Hunsdiecker-Borodin Reaction • Hydrogenolysis of Benzyl Ether • Passerini Reaction • Preparation of Alkylbenzene • Preparation of Amines • Preparation of Carboxylic Acids • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Carboxylic Acids • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Ugi Reaction • Vilsmeier-Haack Reaction

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P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 23020-15-7

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