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CAS No. : | 14208-83-4 | MDL No. : | MFCD03788270 |
Formula : | C8H10N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | BIFLTHWDFNLOTD-UHFFFAOYSA-N |
M.W : | 166.18 | Pubchem ID : | 2736365 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | Stage #1: for 20 h; Heating / reflux Stage #2: With sodium hydroxide In water |
To an ethanol (20mL) solution of 3-aminolsonicotinoic acid (1.4g, 10 mmol), conc. sulfuric acid (2.94g, 30 mmol) was added and refluxed under heating for 20 hours. The reaction liquid was distilled under reduced pressure. Water was added to the obtained residue, which was made its pH to 8-9 with a 2N sodium hydroxide solution under ice-cooling. The precipitated solid was filtered and dried to give ethyl 3-aminoisonicotinate (0.70g, 42percent). Further, the filtrate was extracted with ethyl acetate, and the organic layer was washed with water and saturated aqueous sodium chloride, subsequently, and dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure to give ethyl 3-aminoisonicotinoate (0.30g, 18percent) 1H-NMR (DMSO-d6) δ:1.30(3H,t,J=7.1Hz), 4.28(2H,q,J=7.1Hz), 6.66 (2H,br.s), 7.45(1H,d,J=5.2Hz), 7.73(1H,d,J=5.2Hz), 8.23(1H,s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid; sodium nitrite; In water; at 0 - 90℃; for 1.66667h; | (1) Ethyl 3-aminoisonicotinate (5.55 g) is suspended in water (70 ml), and thereto added conc. sulfuric acid (4.0 ml). The reaction solution is cooled with ice, and a solution of sodium nitrite (2.79 g) in water (30 ml) is added dropwise thereto. The reaction solution is stirred under the same cooling conditions for 20 minutes and then at 90C for 80 minutes. The reaction solution is diluted with water (100 ml) and the solution is adjusted to pH 8 to 9 by addition of saturated aqueous sodium hydrogen carbonate solution, followed by extraction with chloroform. The organic layer is dried over sodium sulfate and evaporated to remove the solvent under reduced pressure. The resulting residue is purified by silica gel column chromatography (eluent : n-hexane/ethyl acetate = 5/1) to give ethyl 3-hydroxyisonicotinate (2.64 g). APCI-MS M/Z:168[M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid; sodium carbonate; In ethanol; water; | EXAMPLE 156A Ethyl 3-aminopyridine-4-carboxylate A suspension of 3-aminopyridine-4-carboxylic acid (2.00 g, 14.5 mmol), prepared by the method of Crum and Fuchsman, J. Het. Chem. 3, 252 (1966), in ethanol (~4 g) was treated with 4.0 g of sulfuric acid and warmed on a steam bath for 4 hours. After cooling to ambient temperature, water (~40 mL) and solid sodium carbonate were added to basify the solution which was then extracted with chloroform (3*). The combined organic extracts were washed with brine, dried over magnesium sulfate and concentrated under reduced pressure. The residue obtained was flash chromatographed on silica gel eluding with 2:1 hexane/ethyl acetate to afford the title compound. 1 H NMR (CDCl3, 300 MHz) delta 1.41 (t, J=7 Hz, 3H), 4.37 (q, J=7 Hz, 2H), 7.60 (d, J=6 Hz, 1H), 7.93 (d, J=6 Hz, 1H), 8.19 (s, 1H). MS (DCI/NH3) m/e 167 (M+H)+, 184 (M+H+NH3)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.68 g (71%) | In toluene; | EXAMPLE 24 3-[2-(cis-6-Methoxy-2,3,3a,4,5,9b-hexahydro-[1H]-benz[e]isoindol-1-yl)ethyl]-pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione dihydrochloride Following the procedure described for Example 21, <strong>[14208-83-4]3-amino-4-ethoxycarbonylpyridine</strong> (0.58 g, 3,5 mmol), prepared by substituting 3,4-pyridinedicarboximide for quinolinimide and the procedure described in J. Chem. Soc., 1045 (1956), Et3 N (1.5 mL, 10.5 mmol), phosgene (1.8 mL of a 1.93M solution in toluene, 3.5 mmol), and the compound resulting from Example 1B (0.60 g, 2.4 mmol) provided 0.68 g (71%) of the desired product which was converted to its HCl salt. m.p. 228-230 C. 1 H NMR (300 MHz, CD3 OD) of the free base delta 1.45-1.49 (m, 1H), 1.66-1.78 (m, 1H), 2.22 (t, 1H), 2.33 (dt, 1H), 2.50-2.68 (m, 3H), 2.77-2.86 (m, 2H), 3.24-3.51 (m, 3H), 3.77 (s, 3H), 4.20 (t, 2 H), 6.71 (dd, 2H), 7.07 (t, 1H), 7.91 (d, 1H), 8.39 (d, 1H), 8.55 (s, 1H). MS (DCI/NH3) m/e 393 (M+H)+. Anal calcd for C22 H24 N4 O3 ·2 HCl: C, 56.78; H, 5.63; N, 12.04. Found: C, 56.3 1; H, 5.63; N, 11.82. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16% | With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 18h;Inert atmosphere; | To a solution of <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (250 mg, 1 .50 mmol) in DMF (2 ml) was added(4-chlorophenyl)acetyl chloride (0.242 ml, 1 .66 mmol). The reaction mixture was stirred under nitrogenfor 18 h then quenched with saturated sodium bicarbonate solution (20 ml) and extracted twice with ethyl acetate (2 x 50 ml). The combined organic layers were filtered through a hydrophobic frit then evaporated to dryness to give the crude product. The crude product was purified with column chromatography (eluted with 0-50% EtOAc in cyclohexane) to give the title compound as a viscousorange gum (188 mg, 39%).LCMS (Method A): Rt = 1.08 mins, MH+ = 319.1The Intermediates given in the following table were prepared in a manner similar to that described for Intermediate 1. Some Intermediates required purification by MDAP (Method E, F or G) in addition to or instead of the aforementioned column chromatography. The preparation of intermediate 79 employed DIPEA (2 eq) and DMAP (0.068 eq) as bases. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
59% | With potassium carbonate; In dichloromethane; water; at 20℃; for 16h; | Intermediate 6: ethyl 3-r(3-phenylpropanoyl)aminol-4-pyridinecarboxylate To a stirred mixture of <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (100 mg, 0.60 mmol) in DCM (3 ml) and saturated aq. potassium carbonate (3 ml) at room temperature was added 3-phenylpropanoyl chloride (0.116 ml, 0.78 mmol). The resultant biphasic solution was stirred rapidly for 16 h then partitioned between DCM (10 ml) and water (20 ml). The separated aqueous phase was extracted with DCM (2 x 20 ml) then the combined organic phase was passed through a hydrophobic frit then concentratedin vacuo to give a yellow oil. The sample was purified by column chromatography (eluted with 0-30% EtOAc in cyclohexane) to give the crude product as a colourless oil (144 mg). The crude product was dissolved in 1:1 MeOH/DMSO (2 ml) then purified in two portions by MDAP using a formic modifier (Method G). The solvent was evaporated under vacuum to give a colouress oil which was dissolved in ethanol (10 ml) then loaded onto a 2 g aminopropyl column that had been preconditioned with two column volumes of ethanol. The aminopropyl column was washed with two column volumes ofethanol then combined fractions concentrated in vacuo to give the title compound as a colourless oil (105 mg, 59%).LCMS (Method A): Rt = 1.04 mins, MH+ = 299.2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9 mg | With potassium carbonate; In tetrahydrofuran; at 60℃; for 4h; | Example 84: 3-({l2-(acetylamino)phenyllmethyl}amino)-4-pyridinecarboxylic acid To a solution of N-[2-(hydroxymethyl)phenyl]acetamide (90 mg, 0.545 mmol) in chloroform (2.0 ml) at0 to 10C was added iodo(trimethyl)silane (90 ul, 0.654 mmol) dropwise. The reaction mixture wasstirred at 25C for 2hr then concentrated to give crude N-(4-[(trimethylsilyl)oxy]methyl}-3- pyridinyl)acetamide.A solution of crude N-(4-[(trimethylsilyl)oxy]methyl}-3-pyridinyl)aceta mide (180 mg, 0.759 mmol), potassium carbonate (166mg, 1.2O4mmol) and <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (100 mg, 0.602mmol) in THF (1 .Oml) was stirred at 60C for 4 hr. The reaction mixture was allowed to cool to 25C then diluted with water (1 ml) then extracted with EtOAc (2 x 10 ml).. The aqueous layer was purified by preparative HPLC (Method I) to give the title compound, 9.0 mg (8%)LCMS (Method D): Rt = 1 .29 mi MH+ 286 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 76h;Inert atmosphere; | Intermediate 9: ethyl 3-I(2-naphthalenylacetyl)aminol-4-pyridinecarboxylate To a stirred solution of <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (250 mg, 1 .50 mmol) and 2-naphthalenylacetic acid (280 mg, 1 .50 mmol) and DIPEA (0.867 ml, 4.96 mmol) in DCM (10 ml) atroom temperature under nitrogen was added 2,4,6-tripropyl-1 ,3,5,2,4,6-trioxatriphosphorinane 2,4,6-trioxide (1340 mg, 50% by weight in ethyl acetate, 2.11 mmol) dropwise over 1 mm. The mixture was allowed to stir for 76 h then saturated aq. sodium hydrogen carbonate solution (10 ml) was added, followed by chloroform (20 ml). The organic layer was isolated then the aqueous layer extracted twice with chloroform (2 x 20 ml). The combined organic phase was passed through a hydrophobic frit thenconcentrated in vacuo to give the crude product as a brown oil. The crude product was purified with column chromatography (eluted with 0-60% EtOAc in cyclohexane) to give the title compound as a pale yellow solid (391 mg, 78%).LCMS (Method A): Rt = 1.13 mins, MH+ = 335.1 The Intermediates given in the following table were prepared in a manner similar to that described for Intermediate 9. Some Intermediates required purification by MDAP (Method E, F or G) in addition to or instead of the aforementioned column chromatography. After MDAP purification, an aminopropyl column was used in some cases to isolate the free base. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In Isopropyl acetate; at 20℃; for 0.5h;Inert atmosphere; | Intermediate 25: ethyl 3-r(3-phenylpropyl)aminol-4-pyridinecarboxylate To a stirred solution of <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (250 mg, 1 .50 mmol) and 3-phenylpropanal (0.218 ml, 1 .66 mmol) and trifluoroacetic acid (0.695 ml, 9.03 mmol) in isopropylacetate (3 ml) was added sodium triacetoxyborohydride (383 mg, 1 .81 mmol) portionwise over 30 sthen the mixture was stirred at room temperature under nitrogen for 30 mm. The reaction mixture wasquenched with saturated sodium hydrogen carbonate (20 ml) then partitioned with ethyl acetate (20ml). The organic layer was isolated then the aqueous phase extracted twice with EtOAc (2 x 20 ml)then the combined organic phase passed through a hydrophobic frit then evaporated under reducedpressure to give the crude product as an orange oil. The crude product was purified with columnchromatography (eluted with 0-20% EtOAc in cyclohexane) to give the title compound as a yellow oil(278 mg, 65%).LCMS (Method A): Rt = 1.03 mins, MH+ = 285.1The Intermediates given in the following table were prepared in a manner similar to that described for Intermediate 25. Some Intermediates required purification by MDAP (Method E, F or G) or preparativeHPLC (Method I) in addition to or instead of the aforementioned column chromatography. After purification, an aminopropyl column was used in some cases to isolate the free base. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
39% | In N,N-dimethyl-formamide; for 18h;Inert atmosphere; | Intermediate 1: ethyl 3-{I(4-chlorophenyl)acetyllam ino}-4-pyridinecarboxylate To a solution of <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (250 mg, 1 .50 mmol) in DMF (2 ml) was added(4-chlorophenyl)acetyl chloride (0.242 ml, 1 .66 mmol). The reaction mixture was stirred under nitrogenfor 18 h then quenched with saturated sodium bicarbonate solution (20 ml) and extracted twice with ethyl acetate (2 x 50 ml). The combined organic layers were filtered through a hydrophobic frit then evaporated to dryness to give the crude product. The crude product was purified with column chromatography (eluted with 0-50% EtOAc in cyclohexane) to give the title compound as a viscousorange gum (188 mg, 39%).LCMS (Method A): Rt = 1.08 mins, MH+ = 319.1 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In Isopropyl acetate; at 20℃; for 16h;Inert atmosphere; | Intermediate 31: ethyl 3-I(3-hydroxypropyl)aminol-4-pyridinecarboxylate To a stirred solution of 3-[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propanal (1.54g, 8.16 mmol), <strong>[14208-83-4]ethyl 3-amino-4-pyridinecarboxylate</strong> (0.68g, 4.08 mmol), TFA (1.89m1, 24.48 mmol) in isopropyl acetate(1 OmI) under nitrogen and at room temperature was added sodium triacetoxyborohydride (1 .73g,8.16 mmol) in a portionwise manner. The mixture was stirred for 16h, then quenched with saturatedsodium hydrogen carbonate solution (50m1) and diluted with EtOAc (50m1). The organic phase was isolated then the aqueous phase reextracted with EtOAc (2 x 50m1) and the combined organic phase passed through a hydrophobic frit then concentrated under reduced pressure to give an orange oil. The crude product was purified with column chromatography (eluted with 0-8% MeOH in DCM) to give the title compound as a yellow solid (338mg, 37%).LCMS (Method A): Rt = 0.48 mins, MH+ = 225.0 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20℃; for 20h; | To a solution of <strong>[14208-83-4]ethyl 3-aminoisonicotinate</strong> (7.0 g, 42.1 mmol) in DMF (40 mL) was added NBS (15.74 g, 88 mmol). The reaction mixture was stirred at room temperature for 20 h. The reaction mixture was diluted with saturated NaHCO3 solution and ethyl acetate. The organic layer was separated and washed with saturated NaHCO3 solution, dried over MgSO4. The filtrate was concentrated in vacuo. The crude product was dissolved in DCM and purified by flash chromatography. The product was eluted with 0-15% ethyl acetate in hexane to give the desired product as a white solid (9.6 g, 70%); HPLC: RT=1.02 min (H2O/ACN with 0.05% TFA, Waters Acquity SDS C18, 2.1×50 mm, 1.7-mum particles, gradient=1.8 min, wavelength=220 nm); MS (ES): m/z=278.9, 280.9 [M+H]+; 1H NMR (400 MHz, CDCl3) delta ppm 7.81 (s, 1H), 6.26 (br. s., 2H), 4.39 (q, J=7.0 Hz, 2H), 1.42 (t, J=7.2 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
41% | With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 50℃; for 18h;Inert atmosphere; | To a solution of <strong>[14208-83-4]ethyl 3-aminoisonicotinate</strong> (4.0 g, 24.07 mmol) in DMF (25 mL) was added NCS (3.54 g, 26.5 mmol) at room temperature. The reaction mixture was then heated at 50 C. under nitrogen for 18 h. The reaction mixture was cooled to room temperature and treated with saturated aqueous NaHCO3 solution and ethyl acetate. The organic layer was separated and washed with brine, dried (MgSO4) and filtered. The filtrate was concentrated in vacuo. The residue was dissolved in DCM and purified by silica gel flash chromatography, eluting with 30% ethyl acetate in hexane to give the desired product as a light yellow solid (2.0 g, 41%); HPLC: RT=0.84 min (H2O/ACN with 0.05% TFA, Waters Acquity SDS BEH C18, 2.1×50 mm, 1.7-mum particles, gradient=1.8 min, wavelength=220 nm); MS (ES): m/z=200.9 [M+H]+; 1H NMR (400 MHz, CDCl3) delta ppm 7.98 (d, J=0.4 Hz, 1H), 7.66 (d, J=0.4 Hz, 1H), 4.38 (q, J=7.3 Hz, 2H), 1.42 (t, J=7.2 Hz, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
At -20C, a solution of <strong>[14208-83-4]ethyl 3-aminopyridine-4-carboxylate</strong> (1.50 g, 9.03 mmol) in a concentrated solution of hydrochloric acid (8 ml) was treated dropwisely with a solution of sodium nitrite (685 mg, 9.93 mmol) in water (7.0 ml). The resulting mixture was stirred 1 h at -15C. A solution of tin chloride dihydrate (6.11 g, 27.1 mmol) in a concentrated solution of hydrochloric acid (4 ml) cooled at -15C was added dropwisely and the resulting mixture was stirred 1 h at -15C. The pH of the reaction was brought to pH = 10-11 with aqueous potassium hydroxide solution (40%) while the temperature is kept at -15C. The reaction mixture was brought to room temperature and extracted twice with ethyl acetate. The combined organic layers were filtered over celite. The filtrate was washed with a saturated sodium chloride solution, dried over magnesium sulfate and evaporated affording 939 mg (49 % of th.) of the title compound which was used as such without further purificiation. LC-MS (Method 5): Rt = 1.09 min; MS (ESIpos): m/z = 182 [M+H]+ -NMR (400 MHz, DMSO-d6) delta [ppm] : 1.293 (7.65), 1.311 (16.00), 1.329 (7.95), 1.334 (1.32), 3.832 (1.57), 4.268 (2.50), 4.286 (7.65), 4.304 (7.59), 4.321 (2.46), 4.486 (6.80), 7.486 (3.27), 7.499 (3.60), 7.810 (4.82), 7.823 (4.56), 8.110 (3.04), 8.778 (6.23). |
Tags: 14208-83-4 synthesis path| 14208-83-4 SDS| 14208-83-4 COA| 14208-83-4 purity| 14208-83-4 application| 14208-83-4 NMR| 14208-83-4 COA| 14208-83-4 structure
[ 1008138-73-5 ]
Ethyl 5-amino-6-methylnicotinate
Similarity: 0.88
[ 1008138-73-5 ]
Ethyl 5-amino-6-methylnicotinate
Similarity: 0.88
[ 1189434-55-6 ]
Ethyl 6-(aminomethyl)nicotinate hydrochloride
Similarity: 0.82
[ 1189983-26-3 ]
Ethyl 2-(aminomethyl)isonicotinate hydrochloride
Similarity: 0.81
[ 1008138-73-5 ]
Ethyl 5-amino-6-methylnicotinate
Similarity: 0.88
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P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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