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Chemical Structure| 142465-05-2 Chemical Structure| 142465-05-2

Structure of 142465-05-2

Chemical Structure| 142465-05-2

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Product Details of [ 142465-05-2 ]

CAS No. :142465-05-2
Formula : C8H6FN3O
M.W : 179.15
SMILES Code : O=C1NC(N)=NC2=C1C(F)=CC=C2
MDL No. :MFCD20547516

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Application In Synthesis of [ 142465-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 142465-05-2 ]

[ 142465-05-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 142465-05-2 ]
  • [ 24629-25-2 ]
  • (2R,3S)-2-((2-amino-5-fluoroquinazolin-4-yl)amino)-3-methylpentan-1-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
A solution of 2-amino-5-fluoroquinazolin-4-ol (200 mg, 1 .12 mmol), DBU (0.333 ml_, 2.23 mmol) in anhydrous DMF (10 ml_) was stirred at rt under a nitrogen atmosphere. BOP (543 mg, 1 .23 mmol) was added portion wise and stirring continued for 15 min. L-isoleucinol (162 mg, 1 .34 mmol) was added and stirring continued for 18h at rt. The solution was purified by preparatory HPLC (Stationary phase: RP XBridge Prep C18 ODB- 5 pm, 30 x 250 mm, Mobile phase: 0.25% NH4HC03 aq., CH3CN). The desired fractions were collected and evaporated to dryness to afford the title compound as an oil. (Rt: 0.79min, m/z = 279 [M+H], Method: B).
 

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