14300-33-5|Dicyclopropylmethanol| Ambeed

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CAS No. :	14300-33-5
Formula :	C₇H₁₂O
M.W :	112.17
SMILES Code :	OC(C1CC1)C2CC2
MDL No. :	MFCD00019249
InChI Key :	PIXLZMHERIHLJL-UHFFFAOYSA-N
Pubchem ID :	84336

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Yield	Reaction Conditions	Operation in experiment
	With bis(2-methoxyethyl) azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 35℃; for 15.0h;	A) 1-(dicyclopropylmethyl)-<strong>[21642-98-8]4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile</strong> (0739) To a mixture of <strong>[21642-98-8]4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile</strong> (5.0 g), triphenylphosphine (13.1 g), dicyclopropylmethanol (7.47 g) and tetrahydrofuran (100 mL) was added bis(2-methoxyethyl) azodicarboxylate (11.7 g) at 0°C. The reaction mixture was stirred at room temperature for 15 hr. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate. The obtained organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was dissolved in diethyl ether, and triphenylphosphine oxide (5 mg) was added. Insoluble material was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give a crude purification product, which was purified by silica gel column chromatography (basic silica gel, hexane/ethyl acetate) to give a crude title compound (8.80 g). MS (ESI+): [M+H]+ 245.3.
8.80g	With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine; In tetrahydrofuran; at 0 - 35℃; for 15.0h;	<strong>[21642-98-8]4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile</strong> (5.0 g), triphenylphosphine (13.1 g), a mixture of di-cyclopropyl-methanol (7.47 g) and tetrahydrofuran (100 mL), azo dicarboxylic acid bis (2-methoxyethyl) a (11.7 g) was added at 0 ° C.. The reaction mixture was stirred for 15 hours at room temperatureThe reaction mixture was added to water and extracted with ethyl acetate. The resulting organic layer was washed with water then with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was dissolved in diethyl ether, was added triphenyl phosphine oxide (5 mg).The insoluble material was collected by filtration. The filtrate was concentrated under reduced pressure. A silica gel column residueIt was purified by chromatography (hexane / ethyl acetate) and purified by silica gel column chromatography after obtaining a crude product (NH, hexane / ethyl acetate) to give the title compound of crude a (8.80 g).

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P222	Do not allow contact with air.
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P230	Keep wetted
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Code	Phrase
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P378
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P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
P402	Store in a dry place.
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P422
P402 + P404	Store in a dry place. Store in a closed container.
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 14300-33-5

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CAS No.: 14300-33-5

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[ 14300-33-5 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed