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Chemical Structure| 14315-16-3 Chemical Structure| 14315-16-3

Structure of 14315-16-3

Chemical Structure| 14315-16-3

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Product Details of [ 14315-16-3 ]

CAS No. :14315-16-3
Formula : C13H12N2O
M.W : 212.25
SMILES Code : O=C(NC1=CC=CC=C1)C2=CC=CC(N)=C2
MDL No. :MFCD00017101

Safety of [ 14315-16-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 14315-16-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14315-16-3 ]

[ 14315-16-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 14315-16-3 ]
  • [ 3032-81-3 ]
  • 3-(3,5-Dichloro-phenylamino)-N-phenyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethylmorpholine;;copper diacetate; In chloroform; water; N,N-dimethyl-formamide; Example 26 3-(3,5-Dichloro-phenylamino)-N-phenyl-benzamide A mixture of 3-amino-N-phenyl-benzamide (2.0 g, 9.4 mmol), <strong>[3032-81-3]3,5-dichloroiodobenzene</strong> (2.65 g, 9.7 mmol), N-ethylmorpholine (1.1 g, 9.5 mmol), and copper(II) acetate (0.1 g, 0.6 mmol) in N,N-dimethylformamide (6 mL) was stirred under an inert atmosphere and heated to reflux. After 120 hours, the mixture was allowed to cool and was stirred into water (300 mL) and acidified with concentrated hydrochloric acid. The mixture was extracted with dichloromethane (300 mL) and the extract separated and washed successively with 2N hydrochloric acid, water, 0.5 M aqueous potassium carbonate, water, and saturated aqueous sodium chloride, then dried over MgSO4. The solution was filtered and stripped of solvent under reduced pressure to leave a solid residue which was subjected to chromatography on a column of silica gel in chloroform to afford the product (0.1 g); m.p. 164-165° C. after recrystallization from ethyl alcohol. Calculated for C19H14Cl2N2O: C, 63.88; H, 3.95; N, 7.84. Found: C, 63.64; H, 4.04; N, 7.61.
  • 2
  • [ 24686-78-0 ]
  • [ 14315-16-3 ]
  • 3-(1-benzoyl-piperidin-4-ylamino)-N-phenyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
21% 3-(l-Benzoyl-piperidin-4-yIamino)-N-phenyl-benzamide. HVB01183, STX2050,C25H25N3O2, MW 399.48To a solution of 4-aminobenzanilide (0.1 g, 0.47 mmol) and N-benzoyl-4-piperidone (0.192 g, 0.94 mmol) in DCE (2ml) was added acetic acid (0.24 ml) and sodium triacetoxyborohydride (0.25 g, 1.18 mmol). The resulting reaction mixture was heated in a microwave for 15 minutes at 100 0C. NaHCO3 was then added, and repeatedly extracted with EtOAc. The organic layers were combined and dried (MgSO4), filtered and evaporated in-vacuo. The crude mixture was purified using flash chromatography (0-100 EPO <DP n="194"/>percent ethyl acetate in hexane) to afford the title compound as a light brown solid, 40 mg,21percent,R.f. 0.55 (EtOAc)3 m.p. 198-200 0C, LCMS: tr = 4.19 min (50percent to 95percent MeOH in water at 0.5 rnl/min to 1.0 ml/min over 5HVUiX mZz M+H 400.50,HPLC: ttau= 4.69 min (100percent MeOH at 0.4 ml/min), 99percent,1H NMR (CDCl3, 400 MHz,): delta 1.41-1.50 (2H, m, CH2), 2.04-2.19 (2H, m, CH2), 3.14(2H, br.s, CH2), 3.63 (IH, s, CH2), 3.80 (IH, s, CH), 4.00-4.05 (IH, m, CH2), 4.64 (IH, br.s, NH)5 6.60-6.63 (2H, m, ArH), 7.34 (IH, t, J=8.0Hz, ArH), 7.39-7.47 (5H, m, ArH),7.60 (2H, d, J=7.6Hz, ArH), 7.68 (IH, br.s, NHCO), 7.70-7.74 (2H, m, ArH).13C NMR (CDCl3, 101 MHz, 10°C): delta 31.8, 32.6, 40.1, 46.4 (CH2), 49.6 (CH), 112.1,119.9(ArCH), 122.7 (ArC), 123.9, 126.7(ArCH), 126.9 (ArC), 128.5, 128.7, 129.0, 129.8(ArCH), 135.5, 138.2, 149.4 (ArC), 165.4, 170.4 (CO), HRMS: Calcd for C25H25N3O2 (M+H)+ 400.2020, found (M+H)+ 400.2017.
 

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