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Chemical Structure| 143782-23-4 Chemical Structure| 143782-23-4

Structure of 143782-23-4

Chemical Structure| 143782-23-4

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Product Details of [ 143782-23-4 ]

CAS No. :143782-23-4
Formula : C9H3F3N2S
M.W : 228.19
SMILES Code : N#CC1=CC=C(N=C=S)C=C1C(F)(F)F
MDL No. :MFCD09800709
InChI Key :TYXKOMAQTWRDCR-UHFFFAOYSA-N
Pubchem ID :11615540

Safety of [ 143782-23-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H314-H332
Precautionary Statements:P260-P261-P264-P270-P271-P280-P301+P312-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P310-P312-P321-P322-P330-P363-P405-P501
Class:8
UN#:1759
Packing Group:

Application In Synthesis of [ 143782-23-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 143782-23-4 ]

[ 143782-23-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 138650-24-5 ]
  • [ 143782-23-4 ]
  • 1-[4-cyano-3-(trifluoromethyl)phenyl]-4-(hydroxymethyl)-2-thioxoimidazolidine-4-carboxylic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% In acetonitrile; for 18h; Compound 42(228 mg, 1 mmol) was added to the solution of compound 57(117 mg, 1 mmol) in acetonitrile (3 mL). The resulting mixture wasstirred for 18 h (LC-MS control). The solventwas removed followingthe standard procedure and the product was subjected to HPLC togive 159 mg (46%) of 63. MS (ESI) [MH] 346. 1H NMR (DMSO-d6)d 12.73 (brs, 1), 10.35 (brs, 1), 8.17 (s, 1), 8.02 (d, J 8.0 Hz, 1),5.17 (brs, 2), 3.72 (t, J 11.2 Hz, 2), 3.62 (d, J 10.0 Hz, 1), 3.46(d, J 11.6 Hz, 1). 13 NMR (90 MHz, DMSO-d6) d 136.42, 132.40,131.98, 131.56, 131.15, 124.37, 120.74, 116.13, 99.71, 64.65, 35.72.
 

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