1438383-89-1|9-Bromo-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one| Ambeed

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Quality Control of [ 1438383-89-1 ] Purity: 97% SDS Specification

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Product Details of [ 1438383-89-1 ]

CAS No. :	1438383-89-1
Formula :	C₁₉H₁₄Br₂O₃
M.W :	450.12
SMILES Code :	O=C1C(Br)CCC2=CC(C3=CC=C(C(CBr)=O)C=C3CO4)=C4C=C21
MDL No. :	MFCD30187854
InChI Key :	NVSLOKHCHIFJDR-UHFFFAOYSA-N
Pubchem ID :	86688372

Safety of [ 1438383-89-1 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H315-H318-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338
Class:	8
UN#:	3261
Packing Group:	Ⅲ

Application In Synthesis of [ 1438383-89-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1438383-89-1 ]

[ 1438383-89-1 ] Synthesis Path-Downstream 1~2

1
[ 334769-80-1 ]
[ 1438383-89-1 ]
(2S,5S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With potassium carbonate; In dichloromethane; at 20℃;	9-bromo-3-(2-bromoacetyl)-10,l l-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one (1.43 g, 3.17 mmol) was treated with a solution of (2S,5S)-l-(tert-butoxycarbonyl)-5-methylpyrrolidine-2- carboxylic acid (800 mg, 3.49 mmol) in dichloromethane (14 mL) and K2CO3 (658 mg, 1.18 mmol). The stirred reaction mixture was stirred at RT and diluted with CH2CI2 and extracted 3X. The organic phase was washed with brine, then dried over MgS04, filtered and concentrated under reduced pressure to afford ((2S,5S)-2-(2-(9-bromo-8-oxo-8,9,10,l l-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)- 2-oxoethyl) 1 -tert-butyl 5-methylpyrrolidine-l,2-dicarboxylate (1.61 g, 84percent).

References: [1]Patent: WO2013/75029,2013,A1 .Location in patent: Page/Page column 211.

2
[ 334769-80-1 ]
[ 1438383-89-1 ]
[ 1378390-35-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	With potassium carbonate; In dichloromethane; at 20℃;	9-bromo-3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one (1.43 g, 3.17 mmol) was treated with a solution of <strong>[334769-80-1](2S,5S)-1-(tert-butoxycarbonyl)-5-methylpyrrolidine-2-carboxylic acid</strong> (800 mg, 3.49 mmol) in dichloromethane (14 mL) and K2CO3 (658 mg, 1.18 mmol). The stirred reaction mixture was stirred at RT and diluted with CH2Cl2 and extracted 3×. The organic phase was washed with brine, then dried over MgSO4, filtered and concentrated under reduced pressure to afford ((2S,5S)-2-(2-(9-bromo-8-oxo-8,9,10,11-tetrahydro-5H-dibenzo[c,g]chromen-3-yl)-2-oxoethyl) 1-tert-butyl 5-methylpyrrolidine-1,2-dicarboxylate (1.61 g, 84percent).

References: [1]Patent: US2013/309196,2013,A1 .Location in patent: Paragraph 0529.

Historical Records

Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

Related Functional Groups of
[ 1438383-89-1 ]

Bromides

A114554 [1378390-29-4]

3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.94

A120808 [1378391-38-8]

3-(2-Bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.87

A358183 [32263-71-1]

6-(Benzyloxy)-2-bromo-3,4-dihydronaphthalen-1(2H)-one

Similarity: 0.86

A429109 [31236-91-6]

2-Bromo-5-methoxy-3,4-dihydronaphthalen-1(2H)-one

Similarity: 0.82

A495502 [1378861-49-4]

2-Bromo-8-methoxy-3,4-dihydronaphthalen-1(2H)-one

Similarity: 0.81

Ketones

A114554 [1378390-29-4]

3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.94

A120808 [1378391-38-8]

3-(2-Bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.87

A358183 [32263-71-1]

6-(Benzyloxy)-2-bromo-3,4-dihydronaphthalen-1(2H)-one

Similarity: 0.86

A704423 [1438383-92-6]

3-Acetyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.86

A704423 [1438383-92-6]

3-Acetyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.86

Related Parent Nucleus of
[ 1438383-89-1 ]

Other Aromatic Heterocycles

A114554 [1378390-29-4]

3-(2-Bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.94

A120808 [1378391-38-8]

3-(2-Bromo-1-hydroxyethyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.87

A704423 [1438383-92-6]

3-Acetyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.86

A704423 [1438383-92-6]

3-Acetyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.86

A704423 [1438383-92-6]

3-Acetyl-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

Similarity: 0.86

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CAS No.: 1438383-89-1

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