14399-63-4|2-(1-Hydroxycyclohexyl)acetic acid| Ambeed

Quality Control of [ 14399-63-4 ]

Product Details of [ 14399-63-4 ]

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CAS No. :

14399-63-4

MDL No. :

MFCD01028654

Formula :

C₈H₁₄O₃

Boiling Point :

Linear Structure Formula :

InChI Key :

M.W :

158.20

Pubchem ID :

Synonyms :

Safety of [ 14399-63-4 ]

Application In Synthesis of [ 14399-63-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 14399-63-4 ]

[ 14399-63-4 ] Synthesis Path-Downstream 1~5

1
[ 2314-36-5 ]
[ 14399-63-4 ]
2-cyclohex-1-enyl-3-(3,5-dichloro-4-hydroxy-phenyl)-acrylic acid [ No CAS ]

Reference： [1]Patent: US2529518,1948,
[2]Patent: US2637745,1948,

2
[ 14399-63-4 ]
[ 18294-87-6 ]
[ 1552-91-6 ]

Reference： [1]Justus Liebigs Annalen der Chemie,1909,vol. 365,p. 248

3
[ 5326-50-1 ]
[ 14399-63-4 ]

Yield	Reaction Conditions	Operation in experiment
		To a solution of X4 (510 mg) in MeOH was added IN aqueous NaOH. The reaction mixture was stirred at 600C for Ih5 and then concentrated in vacuo. The residue was diluted with water, washed with Et2O and the aqueous layer acidified with IN aqueous citric acid and extracted with EtOAc. The organics were dried (MgSO4) and concentrated in vacuo to yield after recrystallization compound X5 (220mg): 1H-NMR (CDCl3, 500MHz) 3.63 (s, IH), 2.45 (s, 2H), 1.22-1.64 (m, 10H) ppm; FIA m/z 157.2 ES".
		[0338] To a solution of X4 (510 mg) in MeOH was added IN aqueous NaOH. The reaction mixture was stirred at 6O0C for Ih, and then concentrated in vacuo. The residue was diluted with water, washed with Et2O and the aqueous layer acidified with IN aqueous citric acid and extracted with EtOAc. The organics were dried (MgSO4) and concentrated in vacuo to yield after recrystallization compound X5 (220mg): 1H-NMR (CDCl3, 500MHz) 3.63 (s, 1 H), 2.45 (s, 2H), 1.22- 1.64 (m, 1 OH) ppm; FIA m/z 157.2 ES".

Reference： [1]Journal of the American Chemical Society,1945,vol. 67,p. 1432,1434
[2]Bulletin de la Societe Chimique de France,1960,p. 1196 - 1201
[3]Journal of Organic Chemistry,1968,vol. 33,p. 3828 - 3838
[4]Patent: WO2007/25307,2007,A2 .Location in patent: Page/Page column 301
[5]Patent: WO2008/106139,2008,A1 .Location in patent: Page/Page column 470

4
[ 14399-63-4 ]
[ 1552-91-6 ]

Reference： [1]Journal of Organic Chemistry,1968,vol. 33,p. 3828 - 3838

5
[ 14399-63-4 ]
KOH-solution [ No CAS ]
[ 18294-87-6 ]
[ 1552-91-6 ]
[ 108-94-1 ]
[ 64-19-7 ]

Reference： [1]Journal of the Chemical Society,1927,p. 357

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Precautionary Statements-General
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Response
Code	Phrase
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
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P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
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Disposal
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P501	Dispose of contents/container to ...
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Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
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H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:
Hazard Statements:	H315-H319-H335	Packing Group:
GHS Pictogram:

[ CAS No. 14399-63-4 ] {[proInfo.proName]}

Quality Control of [ 14399-63-4 ]

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Product Details of [ 14399-63-4 ]

Safety of [ 14399-63-4 ]

Application In Synthesis of [ 14399-63-4 ]

[ 14399-63-4 ] Synthesis Path-Downstream 1~5

Precautionary Statements-General

Prevention

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Disposal

Physical hazards

Health hazards

Environmental hazards

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