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(chloromethanetriyl)tribenzene
(Chloro(4-methoxyphenyl)methylene)dibenzene
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(chloromethanetriyl)tribenzene
methoxybenzene

[ CAS No. 14470-28-1 ] {[proInfo.proName]}

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Chemical Structure| 14470-28-1
Chemical Structure| 14470-28-1
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Quality Control of [ 14470-28-1 ]

COA NMR CNMR HPLC LC-MS

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Product Details of [ 14470-28-1 ]

CAS No. :14470-28-1 MDL No. :MFCD00000814
Formula : C20H17ClO Boiling Point : No data available
Linear Structure Formula :ClC(C6H5)3OCH2 InChI Key :OBOHMJWDFPBPKD-UHFFFAOYSA-N
M.W : 308.80 Pubchem ID :84462
Synonyms :

Safety of [ 14470-28-1 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P305+P351+P338 UN#:
Hazard Statements:H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 14470-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14470-28-1 ]

[ 14470-28-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 14470-28-1 ]
  • [ 20724-73-6 ]
  • 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]-4-[[(4-methoxyphenyl)-diphenyl-methyl]amino]pyrimidin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]-4-[[(4-methoxyphenyl)-diphenyl-methyl]amino]pyrimidin-2-one (E-5) 2'-C-Methylcytidine (38.9 mmol) was dissolved in pyridine (270 mL) and the reaction mixture was cooled down to 0 C. TMSCl (233.4 mmol) was added and the mixture was stirred at room temperature during 4 hours. DMAP (38.9 mmol) and mMTrCl (77.25 mmol) were added and the reaction mixture was stirred at 50 C. during 2 days. The reaction was cooled down to room temperature and a saturated solution of NaHCO3 was added slowly. The mixture was extracted with CH2Cl2 and the organic layer was dried over Na2SO4, filtered and concentrated. Co-evaporations with toluene and CH2Cl2 were done. The crude was dissolved in CH3OH (500 mL) and NH4F (194.5 mmol) was added. The reaction mixture was heated at reflux and stirred during 1 hour. The reaction mixture was cooled down to room temperature and concentrated. The crude was purified by chromatography on a silica gel column (eluent: CH2Cl2/CH3OH 0 to 10%) to give the expected compound as a yellow powder in 89% yield. 1H NMR (CDCl3, 400 MHz) delta (ppm) 1.08 (s, 3H), 3.71-3.84 (m, 2H), 3.81 (s, 3H), 3.90-3.94 (m, 1H), 3.99-4.03 (m, 1H), 5.14 (d, J=7.63 Hz, 1H), 5.31 (s, 1H), 5.79 (brs, 1H), 6.84 (d, J=8.65 Hz, 2H), 7.13 (d, J=8.69 Hz, 2H), 7.21 (d, J=7.35 Hz, 4H), 7.27-7.34 (m, 8H), 7.51 (brs, 1H).
Reference： [1]Patent: US2013/315867,2013,A1 .Location in patent: Paragraph 0441; 0442
  • 2
  • [ 114248-23-6 ]
  • [ 14470-28-1 ]
  • C29H26F2N2O6 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With pyridine; at 20℃;Inert atmosphere; Commercial 2?-deoxy-2?-difluorouridine (140mg) was dissolved in dry pyridine (2.5mL) undernitrogen and 4-methoxytrityl chloride (246mg, 1.5 eq.) added to the solution. The resulting mixturewas stirred overnight at rt. LC-MS showed complete conversion into the 5?-MMTr protected intermediate. To the mixture was then added acetic anhydride (60L, 1.2 eq.) and the reaction stirredat rt for 2h. LC-MS showed complete conversion into the 5?-MMTr-3?-Ac protected intermediate andthe mixture was quenched by addition of methanol. Solvents were removed by evaporation and theresidue partionated between DCM (10mL) and saturated sodium bicarbonate solution (10mL). Thephases were separated and the water layer extracted with DCM (2x10mL). The combined organiclayers were dried over sodium sulphate, filtered and concentrated to dryness. The crude residue wastaken into 80% acetic acid (30mL) and heated at 45C for 5h. The solution was then concentrated todryness and the residue purified by chromatography on silica gel using DCM/EtOH: 100/0, 98/2, 96/4to yield the desired (2R,3R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4,4-difluoro-2-(hydroxymethyl)tetrahydrofuran-3-yl acetate (68mg, 42%).
Reference： [1]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 3468 - 3471
  • 3
  • [ 114248-23-6 ]
  • [ 14470-28-1 ]
  • C31H28F2N2O7 [ No CAS ]
Reference： [1]Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,p. 3468 - 3471

Tags: 14470-28-1 synthesis path| 14470-28-1 SDS| 14470-28-1 COA| 14470-28-1 purity| 14470-28-1 application| 14470-28-1 NMR| 14470-28-1 COA| 14470-28-1 structure

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Categories
Chemistry
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Benzene Compounds
methoxybenzene
Chemistry
Organic Building Blocks
Chlorides
(chloromethanetriyl)tribenzene
Chemistry
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Chemistry
Organic Building Blocks
Protective Groups
Pharmaceutical Intermediate
Antivirals
Cidofovir

Technical Information

• Alkyl Halide Occurrence • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Alkylbenzene • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Vilsmeier-Haack Reaction
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