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Chemical Structure| 1454682-79-1 Chemical Structure| 1454682-79-1

Structure of 1454682-79-1

Chemical Structure| 1454682-79-1

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Product Details of [ 1454682-79-1 ]

CAS No. :1454682-79-1
Formula : C9H9BrN4
M.W : 253.10
SMILES Code : CC1=NC2=NC(NC)=NC=C2C=C1Br

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Application In Synthesis of [ 1454682-79-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1454682-79-1 ]

[ 1454682-79-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1454682-74-6 ]
  • [ 1454682-79-1 ]
  • [ 1454682-72-4 ]
YieldReaction ConditionsOperation in experiment
70% With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 85.0℃;Inert atmosphere; Method B: Sparge a suspension of l-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)urea (4.48 g, 11.8 mmol), 6-bromo-N,7- dimethylpyrido[2,3-d]pyrimidin-2-amine (3.0 g, 11.8 mmol) and K2CO3 (4.91 g, 35.6 mmol) in dioxane (80 mL) and water (20 mL) with argon, treat with tetrakis(triphenylphosphine)palladium (0.685 g, 0.593 mmol) and heat at 85 C overnight. Remove the dioxane under reduced pressure, treat the mixture with EtOAc and brine, separate the layers, dry the organics over Na2S04, concentrate and purify by silica gel chromatography (40% to 100% EtOAc/hexane, 100% EtOAc, 5% MeOH/ EtOAc). Treat the material with CH3CN, heat at 80C for 1 hour, cool to RT and collect the solid via filtration to afford the title compound (3.52 g, 70%> yield) as a pale yellow solid. MS (m z): 425.2 (M+l).
 

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