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Chemical Structure| 145798-60-3 Chemical Structure| 145798-60-3

Structure of 145798-60-3

Chemical Structure| 145798-60-3

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Product Details of [ 145798-60-3 ]

CAS No. :145798-60-3
Formula : C12H12BrNO
M.W : 266.13
SMILES Code : O=C1N(CCCBr)C2=C(C=CC=C2)C=C1

Safety of [ 145798-60-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331-H341
Precautionary Statements:P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 145798-60-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 145798-60-3 ]

[ 145798-60-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 145798-60-3 ]
  • [ 57184-23-3 ]
  • 1-[3-(4-cyclohexanemethyl-1-piperazinyl)-propyl]-2(1H)-quinolinone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N-methyl-acetamide; dichloromethane; Example 1 1-[3-(4-Cyclohexanemethyl-1-piperazinyl)-propyl]-2(1H)-quinolinone 1-(3-Bromopropyl)-2(1H)-quinolinone (250 mg) obtained in Preparation example 1, cyclohexanemethylpiperazine (171 mg), and potassium carbonate (195 mg) were suspended in dimethylformamide (3 ml). The suspension was heated at 80C for 10 hr. Dichloromethane was added to the reaction solution. The mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under the reduced pressure to give an oil. The oil was purified by column chromatography on silica gel to give the title compound (272 mg). 1H NMR (CDCl3) δ (ppm): 0.80 - 0.98 (2H, m), 1.09 - 1.30 (3H, m), 1.42 - 1.55 (1H, m), 1.61 - 1.80 (5H, m), 1.93 (2H, tt, J = 7.7 and 7.2 Hz), 2.13 (2H, d, J = 7.2 Hz), 2.36 - 2.58 (8H, m), 2.48 (2H, t, J = 7.2 Hz), 4.35 (2H, t, J = 7.7 Hz), 6.69 (1H, d, J = 9.5 Hz), 7.18- 7.24 (1H, m), 7.50 - 7.58 (3H, m), 7.66 (1H, d, J = 9.5 Hz). Mass spectrum EIMS, m/z 367 (M+).
 

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