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Chemical Structure| 146368-11-8 Chemical Structure| 146368-11-8

Structure of CY5
CAS No.: 146368-11-8

Chemical Structure| 146368-11-8

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CY5 is a reactive dye for the labeling of amino-groups in peptides proteins and oligonucleotides

Synonyms: Sulfo-Cyanine5

4.5 *For Research Use Only !

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Product Citations

Product Citations

Baryakova, Tsvetelina ; Yu, Marina ; Segatori, Laura ; McHugh, Kevin ;

Abstract: Oral colonic drug delivery systems (CDDSs) are oftentimes associated with a short duration of action and poor tissue specificity. To address these challenges, we engineered an oral prodrug that leverages the engraftment and semi-permanence of gut commensals to create a long-acting colonic drug depot. We show that two synthetic stem peptide probes can be stereoselectively incorporated onto the surface of gut bacteria in C57BL/6 mice following oral administration. We then show that a prodrug consisting of budesonide, a corticosteroid with otherwise limiting side effects used to treat ulcerative colitis (UC), conjugated to one of these probes via a hydrolyzable ester is significantly less bioactive and is cleaved over a period of days to weeks in simulated physiological fluids. This prodrug can be integrated into the bacterial peptidoglycan in vitro and be cleaved into free budesonide over time, thereby improving drug localization and potentially rendering it safer for longer-term use.

Keywords: Bacteria ; peptidoglycan ; colonic drug delivery systems ; corticosteroids ; immunomodulation

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Product Details of CY5

CAS No. :146368-11-8
Formula : C33H40N2O8S2
M.W : 656.81
SMILES Code : O=S(C1=CC2=C([N+](CC)=C(/C=C/C=C/C=C3N(CCCCCC(O)=O)C4=C(C=C(S(=O)(O)=O)C=C4)C/3(C)C)C2(C)C)C=C1)([O-])=O
Synonyms :
Sulfo-Cyanine5
MDL No. :MFCD29477740

Safety of CY5

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
CY5 falls under the category of CY dyes, short for Cyanine, which are characterized by two nitrogen atoms linked by an odd number of methyl units. These compounds are known for their long wavelengths, tunable absorption and emission, high extinction coefficient, good water solubility, and relatively straightforward synthesis[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.52mL

0.30mL

0.15mL

7.61mL

1.52mL

0.76mL

15.23mL

3.05mL

1.52mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
 

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