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Chemical Structure| 19364-66-0 Chemical Structure| 19364-66-0

Structure of Bis-PEG2-acid
CAS No.: 19364-66-0

Chemical Structure| 19364-66-0

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Product Citations

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Baryakova, Tsvetelina ; Yu, Marina ; Segatori, Laura ; McHugh, Kevin ;

Abstract: Oral colonic drug delivery systems (CDDSs) are oftentimes associated with a short duration of action and poor tissue specificity. To address these challenges, we engineered an oral prodrug that leverages the engraftment and semi-permanence of gut commensals to create a long-acting colonic drug depot. We show that two synthetic stem peptide probes can be stereoselectively incorporated onto the surface of gut bacteria in C57BL/6 mice following oral administration. We then show that a prodrug consisting of budesonide, a corticosteroid with otherwise limiting side effects used to treat ulcerative colitis (UC), conjugated to one of these probes via a hydrolyzable ester is significantly less bioactive and is cleaved over a period of days to weeks in simulated physiological fluids. This prodrug can be integrated into the bacterial peptidoglycan in vitro and be cleaved into free budesonide over time, thereby improving drug localization and potentially rendering it safer for longer-term use.

Keywords: Bacteria ; peptidoglycan ; colonic drug delivery systems ; corticosteroids ; immunomodulation

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Product Details of [ 19364-66-0 ]

CAS No. :19364-66-0
Formula : C8H14O6
M.W : 206.19
SMILES Code : OC(CCOCCOCCC(O)=O)=O
MDL No. :MFCD22056315
InChI Key :BOXWYBCUJGWEOJ-UHFFFAOYSA-N
Pubchem ID :13055589

Safety of [ 19364-66-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338
 

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