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Chemical Structure| 14802-18-7 Chemical Structure| 14802-18-7

Structure of 14802-18-7

Chemical Structure| 14802-18-7

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Product Details of [ 14802-18-7 ]

CAS No. :14802-18-7
Formula : C15H11NO
M.W : 221.25
SMILES Code : O=C1C=C(C2=CC=CC=C2)NC3=C1C=CC=C3

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Application In Synthesis of [ 14802-18-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14802-18-7 ]

[ 14802-18-7 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 16619-14-0 ]
  • [ 14802-18-7 ]
YieldReaction ConditionsOperation in experiment
85% With iodine; In dimethyl sulfoxide; at 80℃; for 12h; General procedure: A mixture of 2 (1 mmol) and iodine (1.5 mmol) inDMSO was warmed at 80°C in an oil bath for 12 hours. On completion of the reaction, the reaction mixture was poured onto saturated solution of sodium thiosulfate. The precipitated solid was collected and the desired product was purified by column chromatography using silica gel (60x120 mesh) with increasing percentage of ethyl acetate in hexaneas eluting solvent. The physical data of compounds are provided below.
  • 2
  • [ 53744-32-4 ]
  • [ 16619-14-0 ]
  • [ 14802-18-7 ]
  • 4
  • [ 1352449-02-5 ]
  • [ 16619-14-0 ]
  • [ 14802-18-7 ]
  • [ 104014-46-2 ]
YieldReaction ConditionsOperation in experiment
42%; 23%; 16% With 1,4-di-n-propylpiperazine-2,5-dione; potassium tert-butylate; In dimethyl sulfoxide; at 20℃; for 24h;Glovebox; Sealed tube; Inert atmosphere; General procedure: Substrate (0.5 mmol) and 11 (0 or 0.1 equiv) were added to a pressure tube. Base and anhydrous solvent were added into the tube in the glove box. The tube was then sealed properly and then removed from the glove box. The reaction was carried out at the given temperature for the given reaction time. The reaction was stopped and the pressure tube was cooled to RT. The reaction mixture was quenched with either water or saturated aqueous ammonium chloride (20 mL) and extracted with diethyl ether or dichloromethane or ethyl acetate (320 mL). The combined organic layers were then washed with water (15 mL) and brine(15 mL) and dried over anhydrous sodium sulfate. The filtered solution was concentrated in vacuo and purified by column chromatography to yield products.
  • 5
  • [ 5159-41-1 ]
  • [ 16619-14-0 ]
  • [ 14802-18-7 ]
  • [ 104014-46-2 ]
  • 6
  • [ 40400-13-3 ]
  • [ 16619-14-0 ]
  • [ 14802-18-7 ]
  • [ 104014-46-2 ]
 

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