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CAS No. : | 5234-26-4 | MDL No. : | MFCD00032277 |
Formula : | C10H11NO2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YSZGCNKBKQQPAH-UHFFFAOYSA-N |
M.W : | 177.20 | Pubchem ID : | 21306 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 | UN#: | |
Hazard Statements: | H302-H312-H332 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | 7.25 g [0.05 mol] of <strong>[91-55-4]2,3-dimethylindole</strong> were taken up in 180 ml of methanol and 20 ml of butyl acetate. The solution was placed in a double-walled vessel and cooled to -200C. After a constant ozone/oxygen stream of 38 g/standard m3 had been established, the ozonolysis was commenced. After the ozonolysis was complete, the reaction solution was added dropwise to an ice-cooled methanolic dimethyl sulfide solution {3.4 g (4.1 ml), [0.055 mol] of dimethyl sulfide in 100 ml of methanol} over a period of 1 hour. The reaction solution was then warmed to room temperature and the solvent was subsequently distilled off. The residue was taken up in 100 ml of methanol and the product was crystallized out at 0C.Yield: 5.31 g (60% of theory), 99.8% (GC-% by area), sand-colored to light-brown powder EPO <DP n="10"/>1H-NMR: 300 MHz (CDCI3); 2.22 (s, 3H); 2.65 (s, 3H); 7.12 (t, 1 H); 7.56 {t, 1 H); 7.83 (of, 1 H); 8.65 (of, 1 H)13C-NMR: 75.47 MHz (CDCI3); 25.51 ; 28.59; 120.6; 121.6; 122.2; 131.6; 135.1 ; 169.5; 202.8GC-MS (m/e): 177 [M+], 162, 144, 135, 120 (100%), 106, 92, 77, 65, 51 , 43 | |
60% | 10.0 g [0.0689 mol] of <strong>[91-55-4]2,3-dimethylindole</strong> were taken up in 200 ml of methanol. The solution was placed in a double-walled vessel and cooled to -2O0C. After a constant ozone/oxygen stream of 36 g/standard m3 had been established, the ozonolysis was commenced. After the ozonolysis was complete, the reaction solution was added dropwise to an ice-cooled methanolic thiodiethanol solution {10.1 g [0.083 mol] of thiodiethanol in 100 ml of methanol} over a period of 1 hour.The reaction solution was then warmed to room temperature, part of the solvent was distilled off (leaving 110 ml) and the product was crystallized out at 00C. The precipitated solid was filtered off with suction on a sintered glass filter (pore size 3) and washed with 25 ml of cyclohexane.Yield: 7.3 g (60% of theory), 99.5% (GC-% by area), sand-colored, light-brown powder1H-NMR: 300 MHz (CDCI3); 2.22 (s, 3H); 2.65 (s, 3H); 7.12 (t, 1 H); 7.56 (., 1 H); 7.83 (d, 1 H); 8.65 (of, 1 H)13C-NMR: 75.47 MHz (CDCI3); 25.51 ; 28.59; 120.6; 121.6; 122.2; 131.6; 135.1 ; 169.5; 202.8GC-MS (m/e): 177 [M+], 162, 144, 135, 120 (100%), 106, 92, 77, 65, 51 , 43 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid; nitric acid; at -20 - 0℃; | Step 2: N-(2-Acetyl-6-nitro-phenyl)-acetamide; A solution of N-(2-acetyl-phenyl)-acetamide (1 g, 5.65 mmol) in cone. H2SO4 (2.8 ml_, 45.2 mmol) was cooled to -200C and fuming nitric acid (2 ml_, 33 mmol) was slowly added. The reaction mixture was warmed to 00C and stirred for 7 h. After completion of the starting material, the reaction mixture was quenched with water and extracted with dichloromethane (2X25 ml_). The combined organic layers were washed with brine and water, then dried over anhydrous sodium sulphate and concontrated to dryness. The resulting residue was purified by column chromatography using 1 %methanol in chloroform to get the title compound as yellow solid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With triethylamine; In dichloromethane; | Example 34A N-(2-acetylphenyl)acetamide A solution of 2'-aminoacetophenone (5.0 g, 37 mmol) in dichloromethane (150 mL) at room temperature was treated with triethylamine (5.3 mL, 40 mmol) and acetyl chloride (3.2 mL, 45 mmol), stirred for 3 hours, then washed with water. The aqueous layer was extracted with ethyl acetate (2*20 mL) and the combined extracts were concentrated to provide the desired product (6.5 g, 100%). |
100% | With triethylamine; In dichloromethane; at 20℃; for 3h; | Example 34A N-(2-acetylphenyl)acetamide A solution of 2'-aminoacetophenone (5.0 g, 37 mmol) in dichloromethane (150 mL) at room temperature was treated with triethylamine (5.3 mL, 40 mmol) and acetyl chloride (3.2 mL, 45 mmol), stirred for 3 hours, then washed with water. The aqueous layer was extracted with ethyl acetate (2*20 mL) and the combined extracts were concentrated to provide the desired product (6.5 g, 100%). |
100% | With triethylamine; In dichloromethane; at 0 - 20℃; for 4h; | 2'-aminoacetophenone (2 g, 14.8 mmol),Triethylamine (2.22 mL, 16.3 mmol) in dichloromethane (60 mL) was cooled to 0 C., acetyl chloride (1.26 mL, 17.8 mmol), and the mixture was stirred at room temperature for 4 hours.The reaction solution was washed with water and the aqueous layer was extracted with ethyl acetate.The combined organic layer was dried over anhydrous magnesium sulfate,Filtration and evaporation of the solvent gave the title compound (2.66 g, quant.).Pale yellow solid |
89% | With triethylamine; In dichloromethane; at 0 - 20℃; for 0.5h; | A solution of 2-aminoacetopheone (2.0 g, 14.8 mmol) in DCM (80 mL) was cooled to0 C, and TEA (2.4 mL) and acetyl chloride (2.06 mL, 30 mmol) were added. The resultingsolution was stirred at r.t. for 30 min. NaHCO3 was added and the solution was extracted;the organic layers were then washed with HCl (1M) and brine. The organic layers weredried (MgSO4), filtered and evaporated in vacuo to yield the desired product as a brownsolid, 2.3 g, 89% yield. R.f. 0.49 (EtOAc), m.p. 68-70 C, LCMS: tr = 1.32 min (80% MeOHin water), m/z M-H 175.79, HPLC: tr = 1.60 min (90% acetonitrile in H2O), 94%, 1H NMR(CDCl3, 270 MHz,): 2.15 (3H, s, CH3), 2.58, (3H, s, CH3), 6.99-7.06 (1H, m, ArH), 7.43-7.49(1H, m, ArH), 7.80 (1H, dd, J = 1.5, 8.15 Hz, ArH), 8.65 (1H, dd, J = 1.0, 8.4 Hz, ArH), 11.63(1H, br.s, NH). 13C NMR (CDCl3, 68 MHz): 25.7, 28.8 (CH3), 120.8 (ArCH), 121.7 (ArC),122.4, 131.7, 135.3 (ArCH), 141.1 (ArC), 169.6, 202.9 (CO). HRMS: Calcd. for C10H11NO2(M + H)+ 178.0863, found (M + H)+ 178.0858. |
84.7% | With triethylamine; In dichloromethane; at 0 - 20℃; for 3h; | 4.05 g (0.03 mol) of 2-aminoacetophenone (A1) was dissolved in 100 ml of dichloromethane. Further, 5.3 ml (0.04 mol) of triethylamine was added, and 3.5 ml (0.05 mol) of acetyl chloride was added dropwise with stirring at 0 C to 10 C. After the dropwise addition, the reaction was stirred at room temperature for 3 h, and the reaction mixture was diluted with 100 ml of ethyl acetate. The organic phase is separated and washed until the organic layer is colorless. The mixture was washed once with 30 ml of brine, and the organic phase was dried over anhydrous magnesium sulfate. After filtering off the desiccant and concentrating under reduced pressure, B1 was obtained as a white solid, yield 4.50 g, yield 84.7% |
In 1,1-dichloroethane; at 20℃;Cooling with ice; | Step 1: N-(2-Acetyl-phenyl)-acetamide; To an ice cold slurry of the 1-(2-amino-phenyl)-ethanone (2 g, 14.79 mmol) in dichloroethane (10 ml_), acetyl chloride (1.22 g, 16.2 mmol) was added slowly. The reaction mixture was warmed to room temperature and stirred for 2h. After completion of the reaction, the reaction mixture was quenched with water (10 ml.) and extracted with dichloromethane (2X25 ml_). The combined organic layers were washed with an aq. solution of 5% NaHCO3 followed by water and brine, then dried over anhydrous sodium sulphate and concentrated to dryness. The obtained residue was purified by column chromatography using 2% ethyl acetate in hexane to obtain the title compound as off- white solid which directly used for the next reaction. | |
With triethylamine; In dichloromethane; at 0 - 20℃; for 2h; | To a white suspension of 1 -(2-aminophenyl)ethanone (25 g, 185 mmol) and Et3N (33.4 mL, 240 mmol) in DCM at 0C was added dropwise AcCI (15.70 mL, 222 mmol) in 25 mL DCM. The reaction mixture was then stirred at r.t. for 2 h. After the reaction went to completion as monitored by LC-MS, the reaction mixture was cooled to 0C, and was then quenched with H2O (100 mL). The organic phase was isolated; the aqueous layer was extracted with DCM. The organic phases were combined, and washed with H2O and brine. The resulting organic phase was dried over anhydrous MgSO4, filtered and concentrated to dryness to give crude N-(2- acetylphenyl)acetamide, which was used in the next step without further purification (30g, yield 92%). MS (m/z): 136 (M+H)+. | |
With pyridine; In dichloromethane; at 0 - 20℃; for 3.25h;Inert atmosphere; | General procedure: To a solution of the appropriate 1-(2-aminophenyl)ketone (1.0mmol) and pyridine (0.48mL, 6.0mmol) in dichloromethane (5mL) was added acetyl chloride (1.2mmol) in dichloromethane (2mL) in a dropwise manner at 0C under a nitrogen atmosphere. The resulting solution was stirred for 0.25h at 0C and then brought up to room temperature slowly and monitored to completion by TLC analysis. After 3h, the reaction mixture was quenched with 10% aqueous HCl solution and the aqueous solution was extracted with dichloromethane (3×10mL). The combined organic layers were washed with brine (10mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure to afforded the 1-(2-acetylaminophenyl)ketone adduct, which was dried under reduced pressure for 5h. The ketone (0.51mmol) was dissolved in anhydrous THF (8mL) and a solution of ethynylmagnesium bromide (0.5M THF solution; 1.5mmol) was added at room temperature. The resulting mixture was allowed to reflux for 3h. On completion, the reaction mixture was cooled to room temperature and treated with saturated NH4Cl (7mL). After additional stirring at room temperature for 10min, EtOAc (15mL) was added and the phases were separated. The aqueous phase was extracted with EtOAc (3×5mL) and the combined organic layers were washed with brine (10mL), dried over anhydrous Na2SO4, and concentrated under reduced pressure. Purification by flash column chromatography on silica gel (10% EtOAc/n-hexane as eluent) gave the title compound. | |
With triethylamine; In dichloromethane; at 0 - 20℃; for 2h; | 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile To a white suspension of 1-(2-aminophenyl)ethanone (25 g, 185 mmol) and Et3N (33.4 mL, 240 mmol) in DCM at 0 C. was added dropwise AcCl (15.70 mL, 222 mmol) in 25 mL DCM. The reaction mixture was then stirred at r.t. for 2 h. After the reaction went to completion as monitored by LC-MS, the reaction mixture was cooled to 0 C., and was then quenched with H2O (100 mL). The organic phase was isolated; the aqueous layer was extracted with DCM. The organic phases were combined, and washed with H2O and brine. The resulting organic phase was dried over anhydrous MgSO4, filtered and concentrated to dryness to give crude N-(2-acetylphenyl)acetamide, which was used in the next step without further purification (30 g, yield 92%). MS (m/z): 136 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With sodium hydroxide; In methanol; water; at 20℃; for 6h; | General procedure: An aqueous solution of NaOH (5%, 4 ml) was added slowly to the stirring solution of appropriate aryl aldehyde (1mmol) and <strong>[5234-26-4]N-(2-acetylphenyl)acetamide</strong> (1 mmol) in methanol (20 ml) in a 100 ml conical flask. The stirring was continued at room temperature for 6 hours and the completion of reaction was monitored by TLC. The reaction on completion was poured onto ice cold water, yellow solid was obtained after filteration which was recrystallized from ethanol. The physical data for the characterstic compound is shown below. |
64.4% | With sodium hydroxide; In methanol; at 0℃; for 8h; | 5.31 g (0.03 mol) of 2-acetamidoacetophenone (B1) was dissolved in 100 ml of methanol, Then add 3.18 (0.03 mol) benzaldehyde, and add 30 ml of 5% sodium hydroxide solution dropwise under ice cooling. After the dropwise addition, the reaction was carried out at 0 C for 8 h, and the reaction liquid was poured into 250 ml of ice water to precipitate a large amount of pale yellow solid. Filter by suction, wash the filter cake, dry, C1 is obtained as a pale yellow solid, the yield is 5.09 g, the yield is 64.4%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; In methanol; water; at 20℃; for 6h; | General procedure: An aqueous solution of NaOH (5%, 4 ml) was added slowly to the stirring solution of appropriate aryl aldehyde (1mmol) and <strong>[5234-26-4]N-(2-acetylphenyl)acetamide</strong> (1 mmol) in methanol (20 ml) in a 100 ml conical flask. The stirring was continued at room temperature for 6 hours and the completion of reaction was monitored by TLC. The reaction on completion was poured onto ice cold water, yellow solid was obtained after filteration which was recrystallized from ethanol. The physical data for the characterstic compound is shown below. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In toluene; | EXAMPLE 21 N-[2-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide A suspension of 48 g of <strong>[5234-26-4]N-[2-(1-oxo-1-ethanyl)phenyl]acetamide</strong> and 38 g of N,N-dimethylformamide dimethyl acetal in 150 ml of toluene was heated at reflux for about 16 hours, then concentrated in vacuo to a solid. The solid was recrystallized from 1-chlorobutane to yield 40 g of the title compound; m.p. 90-95 C. Anal. Calcd. for C13 H16 N2 O2: C, 67.2; H, 6.9; N, 12.0. Found: C, 66.8; H, 6.8; N, 11.7. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In pyridine; | Example 80 2-acetaminoacetophenone To a solution of <strong>[25384-14-9]2-aminoacetophenone hydrochloride</strong> (2.0 g) in pyridine (20 ml) was added dropwise acetyl chloride (0.829 ml), and the mixture was refluxed for 20 min. The reaction mixture was poured into ice water, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with 50% aqueous potassium hydrogensulfate solution, saturated aqueous sodium hydrogencarbonate solution and saturated brine, dried over sodium sulfate and purified by silica gel column chromatography to give the title compound (1.180 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A solution of 2-(4-chloro-phenoxy)-phenylamine (298 mg, 1.4 mmol), N-(2-acetyl- phenyl)-acetamide, (200 mg, 1.13 mmol) and chlorotriisopropoxytitanium IV (0.53 ml, 2.26 mmol) in toluene (15 ml) was stirred at r.t. for 4 days. NaHCO3 was added and the mixture was extracted repeatedly with EtOAc, dried (MgSO4) and evaporated to dryness. The residue was re-dissolved in THF (20 ml) and cooled to 0 C, to this was added succinic acid (270 mg, 2.26 mmol) and borane (IM in THF, 2.3 ml, 2.26 mmol). The reaction was slowly warmed to r.t. and stirred for 8 h. NaHCO3 was added and the volatile solvents removed in vacuo, the mixture was then extracted with EtOAc and dried (MgSO4). The crude material was purified by flash chromatography (0-100 % DCM in hexane) to yield the product, 79 mg, 19 % yield. LCMS: tr= 1.42 min (95 % MeOH in water), m/z M-H 365.33, HPLC: U= 4.49 min (90 % ACN in water), 97 %,1H NMR (CDCl3, 270 MHz,): delta 1.17 (3H, X, J = 12 Hz, CH3CH2), 1.56 (3H, d, J = 6.7 Hz, CH3CH), 3.10 (2H, q, J= 14.1 Hz, CH2), 4.22 (IH, d, J= 6.0 Hz, NH), 4.53 (IH, q, J = 13.3 Hz, CH), 4.59 (IH, br.s, NH), 6.66-6.93 (7H, m, ArH), 7.01 (IH, td, J= 7.9, 1.5 Hz, ArH), 7.16-7.31 (4H, m, ArH).13C NMR (CDCl3, 68 MHz): 14.9, 19.9 (CH3), 38.1 (CH2), 50.9 (CH), 111.1, 113.6, 117.0, 118.0, 118.6, 119.5, 125.5, 126.5 (ArCH), 128.6, 127.8 (ArC), 128.3, 129.7 (ArCH), 13.7, 143.3, 146.7, 156.4 (ArC).HRMS: Calcd for C22H23ClN2O (M+Na)+ 389.1386, found (M+Na)+ 389.1391. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | A solution of 2-(4-chloro-phenoxy)-phenylamine (298 mg, 1.4 mmol), N-(2-acetylphenyl)-acetamide, (200 mg, 1.13 mmol) and chloro-tri-isopropoxy-titanium IV (0.53 mL,2.26 mmol) in toluene (15 mL) was stirred at ambient temperature for 4 days. NaHCO3was added and the mixture was extracted with EtOAc, dried (MgSO4) and evaporated todryness. The residue was redissolved in THF (20 mL) and cooled to 0 C, succinic acid(270 mg, 2.26 mmol) and borane (1M in THF, 2.3 mL, 2.26 mmol) were added. The reactionwas slowly warmed to r.t. and stirred for 8h. NaHCO3 was added, and the volatile solventsremoved in vacuo; the mixture was then extracted with EtOAc and dried (MgSO4). Thecrude material was purified by flash chromatography (0-100% DCM in hexane) to yield theproduct as an oil, 79 mg, 19% yield. LCMS: tr = 1.42 min (95% MeOH in water), m/z M-H365.33, HPLC: tr = 4.49 min (90% acetonitrile in water), 97%, 1H NMR (CDCl3, 270 MHz): 1.17 (3H, t, J = 7.2 Hz, CH3CH2), 1.56 (3H, d, J = 6.7 Hz, CH3CH), 3.10 (2H, q, J = 14.1 Hz,CH2), 4.22 (1H, d, J = 6.0 Hz, NH), 4.53 (1H, q, J = 13.3 Hz, CH), 4.59 (1H, br.s, NH),6.66-6.93 (7H, m, ArH), 7.01 (1H, td, J = 7.9, 1.5 Hz, ArH), 7.16-7.31 (4H, m, ArH). 13C NMR(CDCl3, 68 MHz): 14.9, 19.9 (CH3), 38.1 (CH2), 50.9 (CH), 111.1, 113.6, 117.0, 118.0, 118.6,119.5, 125.5, 126.5 (ArCH), 128.6, 127.8 (ArC), 128.3, 129.7 (ArCH), 13.7, 143.3, 146.7, 156.4(ArC). HRMS: Calcd. for C22H23ClN2O (M + Na)+ 389.1386, found (M + Na)+ 389.1391. |
Tags: 5234-26-4 synthesis path| 5234-26-4 SDS| 5234-26-4 COA| 5234-26-4 purity| 5234-26-4 application| 5234-26-4 NMR| 5234-26-4 COA| 5234-26-4 structure
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P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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