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Chemical Structure| 149080-28-4 Chemical Structure| 149080-28-4

Structure of 149080-28-4

Chemical Structure| 149080-28-4

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Product Details of [ 149080-28-4 ]

CAS No. :149080-28-4
Formula : C10H14FN
M.W : 167.22
SMILES Code : NCCCCC1=CC=C(F)C=C1
MDL No. :MFCD09886645

Safety of [ 149080-28-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 149080-28-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 149080-28-4 ]

[ 149080-28-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 59514-18-0 ]
  • [ 149080-28-4 ]
  • 6-bromo-N-(4-(4-fluorophenyl)butyl)-2,3,4,9-tetrahydro-1H-carbazole-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
52% Dissolve 6-bromo-2,3,4,9-tetrahydro-1H-indazole-1-one (66 mg, 0.25 mmol) and 4-p-fluorophenylbutylamine (84 mg, 0.5 mmol) in 5 mL of toluene. A catalytic amount of p-toluenesulfonic acid (0.1 eq) was added and the mixture was refluxed at 140C for 16 h.After the reaction was completed by TLC, the solvent was evaporated and then dissolved with 10 mL of methanol. Sodium borohydride (5.0 eq, 48 mg) was added and refluxed at 80 C. for 4 h. After monitoring the reaction, the reaction was complete.The reaction was quenched with a small amount of water, the organic solvent was distilled off under reduced pressure, and the organic phase was extracted with EA and H2O systems. The combined organic phases were washed with saturated brine and dried over anhydrous Na2SO4. The solvent was distilled off under reduced pressure and subjected to silica gel column chromatography. Product6-Bromo-N-(4-(4-fluorophenyl)butyl)-2,3,4,9-tetrahydro-1H-carbazole-1-amine(94 mg, yield 52%).
 

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