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Chemical Structure| 150783-50-9 Chemical Structure| 150783-50-9

Structure of 150783-50-9

Chemical Structure| 150783-50-9

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Product Details of [ 150783-50-9 ]

CAS No. :150783-50-9
Formula : C13H16F3NO
M.W : 259.27
SMILES Code : CC(C)(C)C(NC1=CC=CC(C(F)(F)F)=C1C)=O

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Application In Synthesis of [ 150783-50-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 150783-50-9 ]

[ 150783-50-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 150783-50-9 ]
  • [ 54396-44-0 ]
YieldReaction ConditionsOperation in experiment
98.5% With hydrogenchloride; In ethanol; Preparation of 2-Methyl-3-Trifluoromethyl-Aniline A solution of 2,2,2'-trimethyl-3'-trifluoromethyl-propionanilide (10 g.) in 75 ml. ethanol and 75 ml. concentrated HCl was refluxed for 24 hours. The reaction mixture was then concentrated in vacuo and diluted with water. It was then basified with 10percent NaOH solution and extracted with ether. The ether extract was washed with water and brine and dried with MgSO4. Removal of ether gave a pale brown liquid (6.65 g., 98.5percent) which was purified by distillation under reduced pressure (b.p. 108°-110° C., 30 mm.) to give 5.73 g. of 2-methyl-3-trifluoromethyl-aniline which solidified on standing. The physical and spectroscopic properties of the product were found to be identical to those of an authentic sample of 2-methyl-3-trifluoromethyl-aniline prepared by the known method below. STR2
 

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