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Chemical Structure| 15102-42-8 Chemical Structure| 15102-42-8

Structure of 15102-42-8

Chemical Structure| 15102-42-8

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Product Details of [ 15102-42-8 ]

CAS No. :15102-42-8
Formula : C3H5Br2NO
M.W : 230.89
SMILES Code : O=C(N)C(Br)CBr
MDL No. :MFCD00031484

Safety of [ 15102-42-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Application In Synthesis of [ 15102-42-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15102-42-8 ]

[ 15102-42-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15102-42-8 ]
  • [ 363-52-0 ]
  • [ 313950-76-4 ]
  • [ 313950-79-7 ]
YieldReaction ConditionsOperation in experiment
22%; 92% With potassium carbonate; In acetonitrile; EXAMPLE 1 2-(5-Fluoro-2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline Stage 1: 5-Fluoro-1,4-benzodioxane-2-carboxamide. A solution containing 50 g of <strong>[363-52-0]3-fluorocatechol</strong> (391 mmol), 99.3 g of 2,3-dibromopropionamide (430 mmol, 1.1 eq.) and 108.1 g of ground potassium carbonate (782 mmol, 2 eq.) in 400 ml of acetonitrile is heated at 60 C. for 16 hours. The reaction mixture is filtered and the filtrate is then evaporated to dryness. 70.5 g of a pale yellow solid are obtained (92% yield; 1/1 mixture of the two regioisomers). Successive recrystallizations from hot ethanol give 16.7 g of pure 5-fluoro-1,4-benzodioxane-2-carboxamide (22% yield). Melting point: 167 C. 1H NMR (400 MHz, CDCl3):6.86-6.71 (m, 3H, aromatics); 6.52 (broad s, 1H, NH); 6.11 (broad s, 1H, NH); 4.72 (dd, J=2.4 and 7.2 Hz, 1H, H2); 4.62 (dd, J=2.4 and 11.6 Hz, 1H, H3A); 4.23 (dd, J=7.2 and 11.6 Hz, 1H, H3B).
 

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