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[ CAS No. 1519-39-7 ] {[proInfo.proName]}

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Chemical Structure| 1519-39-7
Chemical Structure| 1519-39-7
Structure of 1519-39-7 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1519-39-7 ]

CAS No. :1519-39-7 MDL No. :MFCD00151502
Formula : C8H10OS Boiling Point : -
Linear Structure Formula :- InChI Key :FEVALTJSQBFLEU-SNVBAGLBSA-N
M.W : 154.23 Pubchem ID :10913262
Synonyms :

Safety of [ 1519-39-7 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P280-P305+P351+P338-P304+P340 UN#:
Hazard Statements:H302 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1519-39-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1519-39-7 ]

[ 1519-39-7 ] Synthesis Path-Downstream   1~35

  • 1
  • [ 123-29-5 ]
  • [ 1519-39-7 ]
  • [ 96937-98-3 ]
  • 2
  • [ 110-38-3 ]
  • [ 1519-39-7 ]
  • [ 85617-02-3 ]
  • 3
  • [ 41114-00-5 ]
  • [ 1519-39-7 ]
  • [ 1025982-28-8 ]
YieldReaction ConditionsOperation in experiment
95% With lithium diisopropyl amide In tetrahydrofuran 1.) -0 deg C, 30 min, 2.) 0 deg C, 2 h;
  • 4
  • [ 1754-55-8 ]
  • [ 1519-39-7 ]
  • [ 78687-09-9 ]
  • 5
  • [ 1519-39-7 ]
  • [ 106513-42-2 ]
  • [ 155671-22-0 ]
YieldReaction ConditionsOperation in experiment
89% With lithium diisopropyl amide In tetrahydrofuran at -78℃;
  • 6
  • [ 1519-39-7 ]
  • [ 76-04-0 ]
  • [ 105984-82-5 ]
  • 7
  • [ 186581-53-3 ]
  • [ 383-62-0 ]
  • [ 1519-39-7 ]
  • (2S)-2-(chlorodifluoromethyl)-2-<<(4-methylphenyl)sulphenyl>methyl>oxirane [ No CAS ]
  • (2S,RS)-2-(chlorodifluoromethyl)-2-<<(4-methylphenyl)sulphinyl>methyl>oxirane [ No CAS ]
  • (2S,RS)-3-chloro-3,3-difluoro-2-<<(4-methylphenyl)sulphinyl>methyl>-propan-1,2-diol [ No CAS ]
  • (RS)-(Z)-3-chloro-3,3-difluoro-2-methoxy-1-<(4-methylphenyl)sulphinyl>propene [ No CAS ]
  • 8
  • [ 186581-53-3 ]
  • [ 383-62-0 ]
  • [ 1519-39-7 ]
  • (Z)-3-chloro-3,3-difluoro-2-methoxy-1-<(4-methylphenyl)sulphenyl>propene [ No CAS ]
  • (2S,RS)-2-(chlorodifluoromethyl)-2-<<(4-methylphenyl)sulphinyl>methyl>oxirane [ No CAS ]
  • (2S,RS)-3-chloro-3,3-difluoro-2-<<(4-methylphenyl)sulphinyl>methyl>-propan-1,2-diol [ No CAS ]
  • (RS)-(Z)-3-chloro-3,3-difluoro-2-methoxy-1-<(4-methylphenyl)sulphinyl>propene [ No CAS ]
  • 9
  • [ 186581-53-3 ]
  • [ 383-62-0 ]
  • [ 1519-39-7 ]
  • (2S,RS)-2-(chlorodifluoromethyl)-2-<<(4-methylphenyl)sulphinyl>methyl>oxirane [ No CAS ]
  • (RS)-(Z)-3-chloro-3,3-difluoro-2-methoxy-1-<(4-methylphenyl)sulphinyl>propene [ No CAS ]
  • 10
  • [ 186581-53-3 ]
  • [ 426-65-3 ]
  • [ 1519-39-7 ]
  • [ 167010-83-5 ]
  • [ 167010-82-4 ]
  • (2R,RS)-3,3-difluoro-2-<<(4-methylphenyl)sulphinyl>methyl>-4,4,4-trifluorobutan-1,2-diol [ No CAS ]
  • (SR,RS)-3,3-difluoro-2-<<(4-methylphenyl)sulphinyl>methyl>-4,4,4-trifluorobutan-1,2-diol [ No CAS ]
  • 11
  • [ 1519-39-7 ]
  • [ 1128-76-3 ]
  • 1-(3-Chloro-phenyl)-2-((R)-toluene-4-sulfinyl)-ethanone [ No CAS ]
  • 12
  • [ 6413-10-1 ]
  • [ 1519-39-7 ]
  • [ 169888-99-7 ]
  • 13
  • [ 89-91-8 ]
  • [ 1519-39-7 ]
  • [ 172748-96-8 ]
  • 15
  • [ 1519-39-7 ]
  • [ 59936-29-7 ]
  • (2S,SR)-tert-butyl 2-(p-tolylsulfinylacetyl)-pyrrolidine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
78% With lithium diisopropyl amide In tetrahydrofuran at -78.15℃; for 4h;
  • 16
  • [ 28875-17-4 ]
  • [ 1519-39-7 ]
  • [ 310450-35-2 ]
  • (3R,RS)-N-(tert-butoxycarbonyl)-3-amino-1-(p-tolylsulfinyl)-2-butanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1.5h; Stage #2: (S)-N-(tert-butoxycarbonyl)alanine methyl ester In tetrahydrofuran at -25℃; for 3.5h;
  • 17
  • [ 1519-39-7 ]
  • [ 59936-29-7 ]
  • [ 250353-59-4 ]
YieldReaction ConditionsOperation in experiment
78% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 1h; Stage #2: (S)-N-(tert-butoxycarbonyl)proline methyl ester In tetrahydrofuran at -78℃; for 4h;
  • 18
  • [ 1519-39-7 ]
  • [ 22717-57-3 ]
  • [ 371258-74-1 ]
YieldReaction ConditionsOperation in experiment
91% With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - 0℃; for 1h;
  • 19
  • [ 1519-39-7 ]
  • [ 1613-96-3 ]
  • [ 121411-09-4 ]
  • [ 121411-10-7 ]
YieldReaction ConditionsOperation in experiment
52% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: N-(4-methoxybenzylidene)aniline In tetrahydrofuran; hexane at -78℃; for 0.166667h;
  • 20
  • [ 354-38-1 ]
  • [ 1519-39-7 ]
  • C10H10F3NO2S [ No CAS ]
  • 21
  • [ 141-28-6 ]
  • [ 1519-39-7 ]
  • [ 659726-13-3 ]
  • 22
  • [ 128796-39-4 ]
  • [ 31350-96-6 ]
  • (R)-4-(trifluoromethyl)benzyl p-tolyl sulfoxide [ No CAS ]
  • [ 581-80-6 ]
  • [ 1519-39-7 ]
YieldReaction ConditionsOperation in experiment
1: 94% 2: 2% With cesium fluoride In tetrahydrofuran Heating;
  • 23
  • [ 2396-84-1 ]
  • [ 1519-39-7 ]
  • (SR)-1-(p-tolylsulfinyl)-3,5-heptadien-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: (2E,4E)-ethyl hexa-2,4-dienoate In tetrahydrofuran for 2h;
  • 24
  • [ 1519-39-7 ]
  • [ 119-84-6 ]
  • [ 1033725-54-0 ]
YieldReaction ConditionsOperation in experiment
90% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran; hexane at -40℃; for 1h; Inert atmosphere; Stage #2: C6H4(CH2CH2C(O)O) In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
  • 25
  • [ 28875-17-4 ]
  • [ 1519-39-7 ]
  • [ 310450-35-2 ]
YieldReaction ConditionsOperation in experiment
79% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: (S)-N-(tert-butoxycarbonyl)alanine methyl ester In tetrahydrofuran at -25℃; for 12h; Inert atmosphere; optical yield given as %de;
  • 26
  • [ 1519-39-7 ]
  • [ 51987-73-6 ]
  • [ 1105065-36-8 ]
YieldReaction ConditionsOperation in experiment
65% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester In tetrahydrofuran at -25℃; for 12h; Inert atmosphere; optical yield given as %de;
  • 27
  • [ 1519-39-7 ]
  • [ 58561-04-9 ]
  • [ 1105065-38-0 ]
YieldReaction ConditionsOperation in experiment
57% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: N-tert-butoxycarbonyl-L-valine methyl ester In tetrahydrofuran at -25℃; for 12h; Inert atmosphere; optical yield given as %de;
  • 28
  • [ 1519-39-7 ]
  • [ 63096-02-6 ]
  • [ 472999-82-9 ]
YieldReaction ConditionsOperation in experiment
89% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere; Stage #2: N-tert-butoxycarbonyl-L-leucine methyl ester In tetrahydrofuran at -25℃; for 12h; Inert atmosphere; optical yield given as %de;
  • 29
  • [ 1519-39-7 ]
  • [ 6214-64-8 ]
  • [ 1180538-91-3 ]
  • [ 1180538-90-2 ]
YieldReaction ConditionsOperation in experiment
1: 70% 2: 20% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; Stage #2: 6-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid ethyl ester In tetrahydrofuran at -78 - 20℃; Inert atmosphere; chemoselective reaction;
  • 30
  • [ 1519-39-7 ]
  • [ 61837-46-5 ]
  • [ 1279699-94-3 ]
  • 31
  • [ 20920-98-3 ]
  • [ 1519-39-7 ]
  • [ 1323994-13-3 ]
  • [ 1323994-17-7 ]
  • 32
  • [ 18830-44-9 ]
  • [ 1519-39-7 ]
  • (R<SUB>S</SUB>)-methyl 3-fluoro-4-(p-tolylsulfinyl)but-2-enoate [ No CAS ]
  • 33
  • [ 31518-14-6 ]
  • [ 1519-39-7 ]
  • (R)-2-(p-tolylsulfinyl)-1-(5,6-dihydro-4H-pyran-2-yl)ethanone [ No CAS ]
  • 34
  • [ 2524-52-9 ]
  • [ 1519-39-7 ]
  • (R)-(p-tolylsulfinyl)methyl 2-pyridyl ketone [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% Stage #1: (R)-methyl p-tolyl sulfoxide With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: ethyl-2-picolinate In hexane; ethyl acetate at -78℃; for 0.5h; Inert atmosphere; 1. Chemistry. Synthesis of -ketosulfoxides. General Procedure General procedure: A freshly prepared solution of LDA (6.46 mmol, 2 eq.) in THF fromdiisopropylamine (7.11 mmol, 2.2 eq.) in THF (10 mL) at -78 °C and 2 M de nBuLi solution in hexane (3.23 mL, 6.46 mmol, 2 eq.), is added over the corresponding methyl sulfoxide (3.23 mmol, 1 eq.) in THF (10 mL), at -78°C, under argon. After stirring for 30 min. the formed carbanion solution is added over a THF solution (10 mL) of the corresponding ethyl carboxylate (3.23 mmol, 1 eq.), at -78°C, under argon. After stirring for 30 min., the reaction mixture was quenched with saturated NH4Cl, aqueous solution and 1M H2SO4 was added until pH 3-4. The aqueous phase was then extracted with EtOAc (5 x 50 mL), washed with saturated NaHCO3 aqueous solution and saturated NaCl aqueous solution, and dried over Na2SO4. After removing the solvent at vacuo, the residue was purified by flash chromatography, to give the corresponding -ketosulfoxide.
  • 35
  • [ 1519-39-7 ]
  • [ 2150-37-0 ]
  • (R)-1-(3,5-dimethoxyphenyl)-2-(p-tolylsulfinyl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
95% Stage #1: (R)-methyl p-tolyl sulfoxide With lithium dipropan-2-ylazanide In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 3,5-dimethoxybenzoic acid methyl ester In tetrahydrofuran; hexane at -78℃; for 2h; Inert atmosphere;
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[ 1519-39-7 ]

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