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[ CAS No. 152120-55-3 ] {[proInfo.proName]}

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Chemical Structure| 152120-55-3
Chemical Structure| 152120-55-3
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Product Details of [ 152120-55-3 ]

CAS No. :152120-55-3 MDL No. :MFCD02683516
Formula : C20H18N4O4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 378.38 Pubchem ID :-
Synonyms :

Safety of [ 152120-55-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 152120-55-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 152120-55-3 ]
  • Downstream synthetic route of [ 152120-55-3 ]

[ 152120-55-3 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 152120-62-2 ]
  • [ 501-53-1 ]
  • [ 152120-55-3 ]
YieldReaction ConditionsOperation in experiment
75% With sodium hydride In tetrahydrofuran at 0 - 20℃; for 2.5 h; Step 2 N,N'-Bis(benzyloxycarbonyl)-1H-pyrrazole-1-carboxamidine
N-Benzyloxycarbonyl-1H-pyrrazole-1-carboxamidine (58.62 g, 239 mmol) was dissolved in 600 mL of dry THF, and the reaction mixture was cooled to 0° C. and stirred under nitrogen.
To the reaction mixture was added, in portions, 28.8 g of 60percent NaH, maintaining the reaction temperature at 0° C. Benzyl chloroformate (40.9 mL) in 60 mL dry THF was added dropwise to the reaction mixture over a 30 minute period.
The reaction mixture was stirred for two hours at 0° C., then stirred at room temperature for 18 hours.
The reaction mixture was cooled again to 0° C., then quenched by slow addition of saturated aqueous Na2SO4.
The resulting mixture was diluted with EtOAc, and filtered through Celite.
The organic layer was dried (MgSO4), filtered, and concentrated under reduced pressure to give a viscous oil that was washed with hexanes and then dried under reduced pressure to give 67.81 g (75percent) of N,N-bis(benzyloxycarbonyl)-1H-pyrrazole-1-carboxamidine.
Reference: [1] Patent: US2008/207655, 2008, A1, . Location in patent: Page/Page column 17
  • 2
  • [ 501-53-1 ]
  • [ 152120-55-3 ]
Reference: [1] Synthetic Communications, 1993, vol. 23, # 21, p. 3055 - 3060
[2] Tetrahedron Letters, 1993, vol. 34, # 21, p. 3389 - 3392
  • 3
  • [ 13139-17-8 ]
  • [ 152120-62-2 ]
  • [ 152120-55-3 ]
Reference: [1] Tetrahedron Letters, 1993, vol. 34, # 21, p. 3389 - 3392
  • 4
  • [ 75315-63-8 ]
  • [ 152120-62-2 ]
  • [ 152120-55-3 ]
Reference: [1] Synthetic Communications, 1993, vol. 23, # 21, p. 3055 - 3060
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