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CAS No. : | 125238-99-5 | MDL No. : | MFCD00151941 |
Formula : | C24H28N2O6 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LIWKOFAHRLBNMG-FQEVSTJZSA-N |
M.W : | 440.49 g/mol | Pubchem ID : | 2756101 |
Synonyms : |
|
Num. heavy atoms : | 32 |
Num. arom. heavy atoms : | 12 |
Fraction Csp3 : | 0.38 |
Num. rotatable bonds : | 12 |
Num. H-bond acceptors : | 6.0 |
Num. H-bond donors : | 3.0 |
Molar Refractivity : | 118.53 |
TPSA : | 113.96 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | Yes |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.32 cm/s |
Log Po/w (iLOGP) : | 2.4 |
Log Po/w (XLOGP3) : | 3.75 |
Log Po/w (WLOGP) : | 3.89 |
Log Po/w (MLOGP) : | 2.39 |
Log Po/w (SILICOS-IT) : | 2.97 |
Consensus Log Po/w : | 3.08 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.56 |
Log S (ESOL) : | -4.42 |
Solubility : | 0.0168 mg/ml ; 0.0000381 mol/l |
Class : | Moderately soluble |
Log S (Ali) : | -5.84 |
Solubility : | 0.000643 mg/ml ; 0.00000146 mol/l |
Class : | Moderately soluble |
Log S (SILICOS-IT) : | -6.17 |
Solubility : | 0.000298 mg/ml ; 0.000000678 mol/l |
Class : | Poorly soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 3.0 |
Synthetic accessibility : | 4.08 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86.62% | With sodium hydroxide In water; acetone at 0 - 10℃; for 4 h; | B. The suspension 50g146 . 8nmolFmoc-Dab-OH with 700 ml acetone: water = 1:in 1(v/v), in 0-10 °C add 38.4g176 . 1nmol (Boc)2O, 0.5NNaOH adjusting pH= 7.5-8, reaction 4 hours after Fmoc-Dab (Boc)-OH56g processing product, yield 86.62percent, HPLC99 . 4percent. The infrared, nuclear magnetic resonance confirmed correct structure, see Figure 3, Figure 4. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); dichloromethane; at 50℃; | Fmoc-Dbu (Boc) -OH (100 mg, 440.5 G/MOL, 0.23 mmol, 1 eq), DIC (36 mul, 126.20 G/MOL, 0.806 G/CM3, 0.23 mmol, 1 eq) and HOBt (31 mg, 135.12 G/MOL, 0.23 MMOL, 1 eq) were dissolved in dry DMF/DCM (1/1,3 ML). After 5 minutes 1-NAPHTHYLMETHYLAMINE (33 1LL, 157.22 g/mol, 1.092 G/CM3, 0.23 MMOL, 1 eq, Fluka) was added to the reaction mixture. After overnight stirring at 50°C, solvent was evaporated and the residue was dissolved in 30 ML ETHYL acetate and washed three times with 20 ml water. Organic phase was dried with NA2SO4 and evaporated. Residue was purified with flash chromatography. 78.5 mg of 4-N-BOC-AMINO- (S)-2-N -FMOC-AMINO-N"-1-NAPHTHYLMETHYLBUTAN- amide was obtained, yield 60percent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With benzotriazol-1-ol; diisopropyl-carbodiimide; In DMF (N,N-dimethyl-formamide); dichloromethane; at 35℃; | Fmoc-Dbu (Boc) -OH (250.8 mg, 440.5 G/MOL, 0.57 MMOL, 1 eq), DIC (89 mul, 126.20 g/mol, 0. 806 G/CM3, 0.57 mmol, 1 eq) and HOBt (77.6 mg, 135.12 g/mol, 0.57 mmol, 1 eq) were dissolved in dry DMF/DCM (1/1,6 ml). After 5 minutes 2- (3-CHLOROPHENYL) ETHYLAMINE (79 ; J, 155.63 g/mol, 1.119 G/CM3, 0.57 mmol, 1 eq) was added to the reaction mixture. Temperature was raised to 35°C and mixture stirred overnight. Solvent was then evaporated and residue dissolved in DCM, which was washed twice with water and once with brine. Organic phase was subsequently dried with NA2SO4 and evaporated. Residue was purified with silica column chromatography (mobile phase starting from DCM up to 5percent MEOH in DCM). 4- (N-Boc-amino)-N'-2- (3-chloro- phenyl) ethyl- (S)-2- (N"-Fmoc-amino) butanamide was obtained with quantita- tive yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In tetrahydrofuran; at -5℃; for 0.5h; | Example 3; Synthesis of (S)-4-methyInaphthalene-1 -sulfonic acid (3-amino-1-benzyl- oxymethylpropyl)amide (compound 3); Step .; [0073] Fmoc-/--Dab(Boc)-OH (402 mg, 440.50 g/mol 0,91 mmol, 1 eq) was dissolved in dry THF (10 ml). TEA (132 mul, 0,95 mrno., 1 eq) was added and the resulting mixture was cooled to -5 0C in an ice/salt bath. Ethyl chloro- formate (91 mul, 108.53 g/mol, 1.135 g/cm3, 0.95 mmol, 1 eq) was added drop- wise to the mixture. After a 30 min reaction time the formed precipitate was filtered off. The filtrate was added dropwise to a freshly prepared and cooled (-50C) solution of sodium borohydride (43.7mg, 37.83 g/mol, 1.16 mmol, 1.3 eq) in 2 ml of H2O/THF. The resulting mixture was stirred at -5 0C for 1.5 h and then allowed to warm up to room temperature. The solvent was evaporated and the residue dissolved in EtOAc (30 ml) before it was washed successively with a 10percent citric acid solution, a 5percent NaHCO3 solution, water and brine. The organic phase was dried over Na2SO4. Filtration and evaporation gave a crude product which was purified by chromatography to obtain 282 mg (72 percent yield) of (S)-4-(Lambda/-Boc- amino)-2-(A/'-Fmoc-amino)butan-1-ol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.65 g of resin 5a are divided into 5 aliquots. 0.65 g of resin 5b are divided into two equal portions. 0.45 mmol of each N-protected amino acids 6a-f (6a: N(alpha)-Fmoc-N(gamma)-Boc-L-2,4-diaminobutyric acid, twice; 6b: Fmoc-(OTrt)-L-homoserine; 6c: Fmoc-Asp(OtBu)-OH; 6d: Fmoc-Trp(Boc)-OH; 6e: Fmoc-L-4-MePhe-OH; 6f: Fmoc-L-(4-Boc-aminomethyl)Phe-OH each are dissolved in solutions of 5 mL of DMF, 93 muL of DIC and 92 mg of HOBt*H2O. The solutions obtained are stirred for 30 minutes at rt. The solution of activated 6a obtained is divided into 2 equal portions. The portions are transferred to an aliquot of resin 5a and resin 5b to give the side chain protected resins 7a and 8a, respectively. The solutions of activated 6b-e obtained are transferred to the remaining aliquots of resin 5a to give protected resins 7b-e. The solution containing 6f is transferred to the second aliquot of resin 5b to give protected resin 8b. After shaking for 16.5 hours at rt the resins obtained are filtered off and washed with DMF (9.x.10 mL), DCM (6.x.10 mL) and MeOH (6.x.10 mL). The fully protected resins 7a-e and 8a-b obtained are dried under reduced pressure. All chloranil tests are negative. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 0℃; for 1h; | Example 92: 4-[(S)-4-Acetylamino-2-({5-[2-((S)-2-cyclobutylcarbamoyl-pyrrolidin-1- yl)-2-oxo-ethoxy]-1 -phenyl-1 H-pyrazole-3-carbonyl}-amino)-butyryl]-piperazine-1 - carboxylic acid ethyl ester; i) 4-[(S)-4-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)- butyryl]-piperazine-1 -carboxylic acid ethyl ester; To a solution of 1.33 ml 1-ethoxycarbonylpiperazine, 1.27 ml N-ethylmorpholine and 4.0 g N-alpha-Fmoc-N-beta-Boc-L-diaminobutyric acid in 40 ml DMF were added 2.98 g TOTU at 0 0C. After 1 h the reaction mixture was diluted with 100 ml ethyl acetate and subsequently extracted with aqueous LiCI (4 percent), half-saturated aqueous NaHCO3 and water. The crude <n="118"/>product obtained after evaporation of the solvent was used in the subsequent reaction. Yield: 4.96 g colorless foam. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20℃; | Example 28 Synthesis of Compound 28 (S)-9-fluorenylmethyl 10-(2,2-diphenylethyl)-2,2-dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8-ylcarbamate To 2,2-diphenylethylamine (0.95 g, 7.4 mmol) in DCM (10 mL) was added the alpha,beta-unsaturated ketone 27 (5.7 mmol) in DCM (75 mL). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol) and DIC (0.87 mL, 5.6 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum ether:EtOAc (1:1 to 0:1) to give 28 (1.5 g, 31percent) Alternatively, to 2,2-diphenylethylamine (0.97 g, 7.4 mmol) in DCM (20 mL) was added the alpha,beta-unsaturated ketone 27 (5.95 mmol) in DCM (40mL). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol), DIPEA (2.5 mL) and HATU (2.3 g, 6.0 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was taken up in EtOAc (100 mL). The organic layer was washed with saturated sodium bicarbonate solution (2*100 mL), saturated ammonium chloride solution (2*100 mL) and brine (2*100 mL). The organic phase was dried and the solvent removed under reduced pressure. The residue was subjected to column chromatography on silica gel using petroleum ether:EtOAc (3:1 to 1:1 to 0:1) to give 28 (0.86 g, 17percent). | |
With diisopropyl-carbodiimide; In dichloromethane; at 20℃; | Example 28 Synthesis of Compound 28 (S)-9-fluorenylmethyl 10-(2,2-diphenylethyl)-2,2-dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8-ylcarbamate To 2,2-diphenylethylamine (0.95 g, 7.4 mmol) in DCM (10 mL) was added the alpha,beta-unsaturated ketone 27 (5.7 mmol) in DCM (75 mL). After stirring at room temperature for 15 mins, Fmoc-L-2,4-diaminobutyric acid(Boc)-OH (2.4 g, 8.55 mmol) and DIC (0.87 mL, 5.6 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum ether:EtOAc (1:1 to 0:1) to give 28 (1.5 g, 31percent) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diisopropyl-carbodiimide; In dichloromethane; at 20℃; | Example 34 Synthesis of Compound 34 (S)-9-fluorenylmethyl 10-(2-phenylbutyl)-2,2-dimethyl-18-phenyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaoctadecan-8ylcarbamate To 2-phenylbutylamine hydrochloride (0.26 g, 1.4 mmol) in DCM (10 mL) and DIPEA (0.25 mL, 1.8 mmol) was added the alpha,beta-unsaturated ketone 27 (1.06 mmol) in DCM (20 mL). After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (0.7 g, 1.56 mmol) and DIC (0.25 mL, 1.61 mmol) were added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum ether:EtOAc (1:1 to 0:1), providing Compound 34 as a mixture of diastereomers (0.17 g, 21percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diisopropyl-carbodiimide; In dichloromethane; at 20℃; | Example 45 Synthesis of Compound 46 (S)-9-fluorenylmethyl 10-(3,5-dichlorobenzyl)-2,2-dimethyl-4,9,13,16-tetraoxo-3,17-dioxa-5,10,15-triazaiscos-19-en-8-ylcarbamate To 3,5-dichlorobenzylamine (0.49 g, 2.8 mmol) in DCM (5 mL) was added the alpha,beta-unsaturated ketone 45 (2.12 mmol) in DCM (10 mL). After stirring at room temperature for 15 mins, Fmoc-diaminobutyric acid(Boc)-OH (1.35 g, 3.1 mmol) and DIC (0.5 mL, 3.2 mmol) was added. The reaction was stirred at room temperature overnight. The DCM was removed by rotary evaporation and the residue was subjected to column chromatography on silica gel using petroleum ether:EtOAc (1:1 to 0:1), providing compound 46 (0.48 g, 22percent). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,4,6-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; HATU; In N,N-dimethyl-formamide; at 20 - 25℃; for 16h; | EXAMPLE 2-19: Production of (S)-4-amino-18,20-dimethyl-12-(morpholine-4-carbonyl)-7-thia-3,5,11,15-tetraazatricyclo [15.3.1.12,6]docosa-1(20),2,4,6(22),17(21),18-hexaene-10,16-dione (Compound 70) [Show Image] Step 1: Preparation of [(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutyl]carbamic acid tert-butyl ester [Show Image] (S)-4-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid (150 mg, 0.341 mmol) was dissolved in N,N-dimethylformamide (1.0 ml), and then 2-3H-1,2,3-triazolo[4,5-b]pyridin-3-ol (51 mg, 0.377 mmol), O-(7-azabenzotriazole-1-yl)-N,N,N',N-tetramethyluroniumhexafluorophosphate (148 mg, 0.377 mmol), 2,4,6-trimethylpyridine (91 mul), and morpholine (45 mul, 0.512 mol) were added thereto at room temperature. After the mixture was stirred at room temperature for 16 hours, a saturated aqueous sodium chloride solution (20 ml) was added to stop the reaction. The mixture was extracted three times with ethyl acetate (20 ml). The ethyl acetate extraction solutions were combined together, and sequentially washed with a saturated aqueous sodium bicarbonate solution (20 ml) and a saturated aqueous sodium chloride solution (20 ml). The washed ethyl acetate solution was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (developing solvent: n-hexane:ethyl acetate = 1:1) to yield [(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutyl]carbamic acid tert-butyl ester (172.2 mg) as a white amorphous material. Physicochemical properties of [(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-morpholin-4-yl-4-oxobutyl]carbamic acid tert-butyl ester: Molecular weight: 509.ESI (LC/MS positive mode): m/z = 510 (M+H+), retention time: 2.67 minutes (developing solvent: A, acetonitrile containing 0.05percent trifluoroacetic acid; B, 0.05percent aqueous trifluoroacetic acid solution; B, 10percent (0 min) --> 95percent (3.5 min) --> 10percent (4.5 min); flow rate, 4 ml/min, column: Waters Sunfire C18, 5 mum, 4.6 x 50 mm) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
EXAMPLE 2-20: Production of (S)-4-amino-18,20-dimethyl-12-morpholin-4-ylmethyl-7-thia-3,5,11,15-tetraazatricyclo [15.3.1.12,6]docosa-1(20),2(22),3,5,17(21),18-hexaene-10,16-dione (Compound 71) [Show Image] Step 1: Preparation of [(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-hydroxybutyl]carbamic acid tert-butyl ester [Show Image] (S)-4-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid (493 mg, 1.12 mmol) was dissolved in tetrahydrofuran (1 ml), and then isobutyl chloroformate (0.15 ml, 1.14 mmol) and N-methylmorpholine (0.125 ml, 1.15 mmol) were added thereto at -15°C. After stirring for one hour, the precipitate was filtrated and washed with tetrahydrofuran (7 ml). The filtrate was cooled to -15°C, and an aqueous solution (4 ml) of sodium borohydride (127 mg, 3.36 mmol) was dropwise added thereto. After stirring for 30 minutes, water (25 ml) was added to the solution and extracted three times with ethyl acetate (20 ml). The ethyl acetate solution was dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (developing solvent: dichloromethane:methanol = 50:1) to yield [(S)-3-(9H-fluoren-9- ylmethoxycarbonylamino)-4-hydroxybutyl]carbamic acid tert-butyl ester (411 mg) as a colorless oily material. Physicochemical properties of [(S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-4-hydroxybutyl]carbamic acid tert-butyl ester: Molecular weight: 426.ESI (LC/MS positive mode): m/z = 427 (M+H+)Chemical shift value delta in 1H-NMR (400 MHz, in dimethylsulfoxide d-6): 1.30-1.46 (10H, m), 1.61-1.73 (1H, m), 2.80-3.06 (2H, m), 3.23-3.46 (3H, m), 4.18-4.36 (3H, m), 4.65 (1H, t, J=5.3 Hz), 6.70 (1H, d, J=10.0 Hz), 7.08 (1H, d, J=8.2 Hz), 7.33 (2H, t, J=7.6 Hz), 7.42 (2H, t, J=7.3 Hz), 7.69-7.74 (2H, m), 7.89 (2H, d, J=7.8 Hz). |
Tags: 125238-99-5 synthesis path| 125238-99-5 SDS| 125238-99-5 COA| 125238-99-5 purity| 125238-99-5 application| 125238-99-5 NMR| 125238-99-5 COA| 125238-99-5 structure
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P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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