Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 153034-82-3 | MDL No. : | MFCD03095290 |
Formula : | C6H3FINO | Boiling Point : | 304.2°C at 760 mmHg |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 251.00 g/mol | Pubchem ID : | 9992328 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46% | Stage #1: With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -70℃; for 2 h; Stage #2: at -70 - 20℃; |
To a solution of diisopropylamine (174.4g, 1 .73 mol) in dry THF (3 L) was added dropwise 2.5 M solution of n-BuLi in hexane (685 mL, 1 .71 mol) at -10°C. The resulting mixture was stirred at 0°C for 35 min. The mixture was cooled to -70°C and a solution of 2-fluoro-3-iodopyridine (I-26) (350 g, 1 .57 mol) in dry THF (1 L) was added. The mixture was stirred at -70°C for 2 hr. HCOOEt (128 g, 1 .73 mol) was added dropwise at -70°C. After the addition, the mixture was allowed to warm to room temperature and quenched with ice water (4 L). The mixture was diluted with EtOAc (4 L) and washed with brine (500 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The residue was purified by silica gel chromatography eluted with petroleum:EtOAc = 10:1 to afford 2-fluoro-4-iodonicotinaldehyde (I-27) (180 g, 46percent) as a yellow solid.1H NMR (400 MHz, CDCI3) δ ppm 10.08 (s, 1 H), 7.91 (d, 1 H), 7.81 (d, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene In water; <i>tert</i>-butyl alcohol at 20℃; for 1.25 h; | To a stirred solution of 2-fluoro-4-iodopyridine-3- carboxaldehyde (10.Og5 39.8 rnmol) in tert-butanol (350 mL) and water (100 niL) at room temperature were added 2-methyl-2-butene (42.1 ml, 398 mmol), sodium phosphate, monobasic, monohydrate (60.5 g, 438 mmol) and sodium chlorite (18.0 g, 199 mmol). The reaction mixture was stirred at room temperature for 75 min. The reaction mixture was diluted with dichloromethane and a 6M aqueous solution of hydrochloric acid was added until pH ~2. EPO <DP n="196"/>T/US2006/016344The water layer was extracted with dichloromethane. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. Purification by MPLC (CH2Cl2MeOH+ 1percent AcOH: 100/0 to 80/20) afforded 2-fluoro-4-iodonicotinic acid (10.63 g, 39.8 mmol, 100percent yield). MS (ESI pos. ion) m/z: 268 (MH+). Calc'd exact mass for C6H3FINO2: 267. |
[ 884494-84-2 ]
Methyl 2-fluoro-4-iodonicotinate
Similarity: 0.80
[ 882679-90-5 ]
5-Chloro-2-fluoronicotinaldehyde
Similarity: 0.65
[ 158669-26-2 ]
4-Iodo-2-methoxynicotinaldehyde
Similarity: 0.65
[ 882679-90-5 ]
5-Chloro-2-fluoronicotinaldehyde
Similarity: 0.65
[ 1232432-20-0 ]
4-Chloro-2-fluoronicotinaldehyde
Similarity: 0.65
[ 884494-84-2 ]
Methyl 2-fluoro-4-iodonicotinate
Similarity: 0.80
[ 158669-26-2 ]
4-Iodo-2-methoxynicotinaldehyde
Similarity: 0.65