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[ CAS No. 1535-73-5 ]

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Chemical Structure| 1535-73-5
Chemical Structure| 1535-73-5
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Product Details of [ 1535-73-5 ]

CAS No. :1535-73-5 MDL No. :MFCD00041511
Formula : C7H6F3NO Boiling Point : 195.9°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :177.12 g/mol Pubchem ID :73753
Synonyms :

Safety of [ 1535-73-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H312-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1535-73-5 ]

  • Upstream synthesis route of [ 1535-73-5 ]
  • Downstream synthetic route of [ 1535-73-5 ]

[ 1535-73-5 ] Synthesis Path-Upstream   1~13

  • 1
  • [ 914636-35-4 ]
  • [ 1535-73-5 ]
Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 5, p. 373 - 377
  • 2
  • [ 39065-91-3 ]
  • [ 1535-73-5 ]
Reference: [1] European Journal of Organic Chemistry, 2008, # 17, p. 2875 - 2880
  • 3
  • [ 95-57-8 ]
  • [ 1535-73-5 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1986, # 6, p. 925 - 929
  • 4
  • [ 766-51-8 ]
  • [ 1535-73-5 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1986, # 6, p. 925 - 929
  • 5
  • [ 97608-46-3 ]
  • [ 1535-73-5 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1986, # 6, p. 925 - 929
  • 6
  • [ 450-96-4 ]
  • [ 1535-73-5 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1986, # 6, p. 925 - 929
  • 7
  • [ 450-96-4 ]
  • [ 1535-73-5 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 12, p. 4160 - 4184
  • 8
  • [ 1535-73-5 ]
  • [ 2995-45-1 ]
Reference: [1] Journal of Organic Chemistry, 2015, vol. 80, # 16, p. 7876 - 7883
  • 9
  • [ 1535-73-5 ]
  • [ 959235-95-1 ]
Reference: [1] Journal of Medicinal Chemistry, 1998, vol. 41, # 10, p. 1598 - 1612
  • 10
  • [ 1535-73-5 ]
  • [ 467451-91-8 ]
Reference: [1] Journal of Medicinal Chemistry, 1998, vol. 41, # 10, p. 1598 - 1612
[2] Patent: WO2009/133387, 2009, A1,
  • 11
  • [ 1535-73-5 ]
  • [ 198206-33-6 ]
YieldReaction ConditionsOperation in experiment
14%
Stage #1: With sulfuric acid; sodium nitrite In water at -5℃; for 0.25 h;
Stage #2: With potassium iodide In water at 20℃;
l-Iodo-3-(trifluoromethoxy)benzene:; To 3-(trifluoromethoxy)beπzenamine (17.7 g, 100.00 mmol) was added a solution OfNaNO2 (7.4 g, 115.62 mmol) in H2O (80 ml). H2SO4 (25 g, 250.00 mmol) was added dropwise with stirring at -5 °C. The resulting solution was kept at -5 °C for 15 minutes. To this solution was added a solution of KI (20 g, 120,48 mmol) in H2O (60 ml) dropwise, The resulting solution was stirred overnight at room temperature and extracted with EtOAc (2 X 100 mL). The combined organic layers were washed with Na2SO3/H2O (2 X 50 mL), dried over Na2SO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography to afford 4.0 g (14percent) of l-iodo-3- (trifluoromethoxy)benzene.
Reference: [1] Patent: WO2006/55187, 2006, A1, . Location in patent: Page/Page column 99-100
  • 12
  • [ 1535-73-5 ]
  • [ 887267-47-2 ]
Reference: [1] Patent: WO2009/3077, 2008, A1, . Location in patent: Page/Page column 140
  • 13
  • [ 1535-73-5 ]
  • [ 116369-25-6 ]
  • [ 887267-47-2 ]
Reference: [1] Patent: WO2011/3684, 2011, A1, . Location in patent: Page/Page column 25
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