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[ CAS No. 1535-75-7 ]

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Chemical Structure| 1535-75-7
Chemical Structure| 1535-75-7
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Product Details of [ 1535-75-7 ]

CAS No. :1535-75-7 MDL No. :MFCD00035959
Formula : C7H6F3NO Boiling Point : 170.2°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :177.12 g/mol Pubchem ID :73754
Synonyms :

Safety of [ 1535-75-7 ]

Signal Word:Danger Class:3
Precautionary Statements:P261-P280-P305+P351+P338 UN#:1993
Hazard Statements:H225-H302-H312-H315-H319-H332-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1535-75-7 ]

  • Upstream synthesis route of [ 1535-75-7 ]
  • Downstream synthetic route of [ 1535-75-7 ]

[ 1535-75-7 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 1535-75-7 ]
  • [ 2252-44-0 ]
YieldReaction ConditionsOperation in experiment
34.0 %Chromat.
Stage #1: at 40℃; for 0.5 h;
Stage #2: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In sulfuric acid at 0 - 5℃; for 1.5 h;
EXAMPLE 3 (COMPARATIVE) Preparation of l-bromo-3-trifluoromethoxybenzene with DBI in concentrated sulphuric acid. 30.1 g of concentrated sulphuric acid (95-98percent) are placed in a 100 ml reactor and 10.1 g of 2-trifluoromethoxyaniline are added, dropwise. During said operation the temperature is maintained at approximately 400C for approximately 30 minutes.Once a uniform solution has been obtained, it is cooled to 0-50C using a cryostat and the portions of DBI are metered. During addition of the brominating agent, which takes approximately 1 hour, the mixture gradually turns brown. After completion of the reaction (30 minutes) a gas chromatograph analysis is performed: 13.6percent of 2-trifluoromethoxyaniline reagent, 34.0percent of mono-bromo-derivative as per the title, >40percent of di-bromo- and tri-bromo-derivatives.
66.6 %Chromat.
Stage #1: at 40 - 45℃;
Stage #2: With N-Bromosuccinimide In sulfuric acid at 0 - 5℃; for 1.5 h;
EXAMPLE 4 (COMPARATIVE) Preparation of l-bromo-3-trifluoromethoxybenzene with NBS in concentrated sulphuric acid. 30.3 g of concentrated sulphuric acid (95-98percent) are placed in a 100 ml reactor and 10 g of 2-trifluoromethoxyaniline are added, dropwise, as in the previous example at approximately 40-450C. Once a uniform solution has been obtained, it is cooled to 0- 5°C with cryostat. 10.1 g of NBS are metered in portions over a period of 1 hour, then left to complete for a further 30 minutes. The mixture gradually turns yellow and then brown. A gas chromatograph analysis is performed at the end of the reaction:15.3percent of 2-trifluoromethoxyaniline, 66.6percent of mono-bromo-derivative as per the title, 11.1 percent of di-bromo and tri-bromo-derivatives.
Reference: [1] Patent: WO2007/107820, 2007, A2, . Location in patent: Page/Page column 8-9
[2] Patent: WO2007/107820, 2007, A2, . Location in patent: Page/Page column 9
  • 2
  • [ 1535-75-7 ]
  • [ 103008-51-1 ]
  • [ 37526-59-3 ]
Reference: [1] Patent: US6610853, 2003, B1,
  • 3
  • [ 1535-75-7 ]
  • [ 103008-51-1 ]
Reference: [1] Patent: US6365780, 2002, B1, . Location in patent: Page column 5
[2] Patent: US6365780, 2002, B1, . Location in patent: Page column 6
[3] Patent: US6365780, 2002, B1, . Location in patent: Page column 5
  • 4
  • [ 1535-75-7 ]
  • [ 63968-85-4 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 3, p. 886 - 896
  • 5
  • [ 1535-75-7 ]
  • [ 149125-30-4 ]
Reference: [1] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 21 - 39
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 1, p. 40 - 64
[3] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1248 - 1251
  • 6
  • [ 1535-75-7 ]
  • [ 175278-09-8 ]
Reference: [1] Patent: WO2007/107820, 2007, A2, . Location in patent: Page/Page column 7
  • 7
  • [ 1535-75-7 ]
  • [ 396075-91-5 ]
Reference: [1] Patent: WO2011/79102, 2011, A1,
[2] Patent: WO2011/79103, 2011, A1,
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