Home Cart 0 Sign in  
X

[ CAS No. 1538-75-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
3d Animation Molecule Structure of 1538-75-6
Chemical Structure| 1538-75-6
Chemical Structure| 1538-75-6
Structure of 1538-75-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1538-75-6 ]

Related Doc. of [ 1538-75-6 ]

Alternatived Products of [ 1538-75-6 ]

Product Details of [ 1538-75-6 ]

CAS No. :1538-75-6 MDL No. :MFCD00008842
Formula : C10H18O3 Boiling Point : -
Linear Structure Formula :- InChI Key :PGZVFRAEAAXREB-UHFFFAOYSA-N
M.W : 186.25 Pubchem ID :15234
Synonyms :

Safety of [ 1538-75-6 ]

Signal Word:Danger Class:8,3
Precautionary Statements:P280-P305+P351+P338-P310 UN#:2920
Hazard Statements:H225-H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1538-75-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1538-75-6 ]
  • Downstream synthetic route of [ 1538-75-6 ]

[ 1538-75-6 ] Synthesis Path-Upstream   1~35

  • 1
  • [ 75-85-4 ]
  • [ 1538-75-6 ]
  • [ 38222-83-2 ]
  • [ 108154-12-7 ]
  • [ 108154-13-8 ]
Reference: [1] Bulletin de la Societe Chimique de France, 1986, # 2, p. 307 - 313
[2] Bulletin de la Societe Chimique de France, 1986, # 2, p. 307 - 313
  • 2
  • [ 124-63-0 ]
  • [ 75-98-9 ]
  • [ 3282-30-2 ]
  • [ 1538-75-6 ]
Reference: [1] Tetrahedron, 1993, vol. 49, # 8, p. 1535 - 1540
  • 3
  • [ 75-98-9 ]
  • [ 3282-30-2 ]
  • [ 1538-75-6 ]
Reference: [1] Tetrahedron, 1993, vol. 49, # 8, p. 1535 - 1540
  • 4
  • [ 368-44-5 ]
  • [ 1538-75-6 ]
  • [ 1344680-35-8 ]
  • [ 3282-30-2 ]
Reference: [1] Doklady Chemistry, 2011, vol. 439, # 2, p. 219 - 222
  • 5
  • [ 17530-24-4 ]
  • [ 4388-88-9 ]
  • [ 1538-75-6 ]
  • [ 815-17-8 ]
  • [ 75-98-9 ]
Reference: [1] Journal of Organic Chemistry, 1981, vol. 46, # 20, p. 3997 - 4000
  • 6
  • [ 109-97-7 ]
  • [ 1538-75-6 ]
  • [ 5176-27-2 ]
Reference: [1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 26, p. 4327 - 4332
  • 7
  • [ 1538-75-6 ]
  • [ 754-10-9 ]
Reference: [1] Justus Liebigs Annalen der Chemie, 1874, vol. 173, p. 372
  • 8
  • [ 1538-75-6 ]
  • [ 110-60-1 ]
  • [ 68076-36-8 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 9
  • [ 646-19-5 ]
  • [ 1538-75-6 ]
  • [ 99733-18-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 10
  • [ 646-25-3 ]
  • [ 1538-75-6 ]
  • [ 216961-61-4 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 11
  • [ 124-09-4 ]
  • [ 1538-75-6 ]
  • [ 51857-17-1 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 12
  • [ 1538-75-6 ]
  • [ 106-47-8 ]
  • [ 65854-91-3 ]
Reference: [1] Chemical Communications, 2013, vol. 49, # 40, p. 4552 - 4554
  • 13
  • [ 1538-75-6 ]
  • [ 25617-34-9 ]
  • [ 125686-52-4 ]
Reference: [1] Chemical Communications, 2013, vol. 49, # 40, p. 4552 - 4554
  • 14
  • [ 1538-75-6 ]
  • [ 1939-19-1 ]
  • [ 25617-34-9 ]
  • [ 125686-52-4 ]
Reference: [1] Chemical Communications, 2013, vol. 49, # 40, p. 4552 - 4554
  • 15
  • [ 536-90-3 ]
  • [ 1538-75-6 ]
  • [ 56619-93-3 ]
Reference: [1] Chemical Communications, 2013, vol. 49, # 40, p. 4552 - 4554
  • 16
  • [ 1538-75-6 ]
  • [ 56619-93-3 ]
Reference: [1] Tetrahedron, 1995, vol. 51, # 45, p. 12263 - 12276
  • 17
  • [ 7462-86-4 ]
  • [ 1538-75-6 ]
  • [ 124443-68-1 ]
Reference: [1] Journal of Organic Chemistry, 1990, vol. 55, # 4, p. 1399 - 1401
  • 18
  • [ 1538-75-6 ]
  • [ 109-76-2 ]
  • [ 75178-96-0 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 19
  • [ 117-34-0 ]
  • [ 1538-75-6 ]
  • [ 19444-84-9 ]
  • [ 1351453-88-7 ]
  • [ 52079-23-9 ]
  • [ 19444-84-9 ]
Reference: [1] Organic Letters, 2013, vol. 15, # 6, p. 1170 - 1173
  • 20
  • [ 462-94-2 ]
  • [ 1538-75-6 ]
  • [ 51644-96-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4457 - 4478
  • 21
  • [ 4395-98-6 ]
  • [ 1538-75-6 ]
  • [ 91419-52-2 ]
Reference: [1] Synthetic Communications, 1990, vol. 20, # 12, p. 1757 - 1767
  • 22
  • [ 504-24-5 ]
  • [ 1538-75-6 ]
  • [ 98400-69-2 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012, vol. 51, # 8, p. 1168 - 1172,5
  • 23
  • [ 1538-75-6 ]
  • [ 7355-55-7 ]
  • [ 137281-08-4 ]
YieldReaction ConditionsOperation in experiment
95% at 120℃; Pivaloylation of the 2-amino moiety of pyrrolo[2,3-„]pyrimidine 8 gave 9 (95percent yield). The purpose of this step was to decrease the polarity and increase the solubility of 8. The product 9 directly precipitated from the reaction mixture by the addition of hexane and ethyl acetate (5: 1). Mannich reaction on 9 afforded 10 in 70-80percent yield. KOAc was used to form a buffer, at which pH the pivalic protection group was stabilized. Pd-catalyzed debenzylation of 10 provided 11 in 90percent yield. None of these steps require chromatographic purification. For 10, after removal of the solvent and addition of acetone and filteration, the filtrate was distilled to afford a semisolid, crude 10, which can be directly used in the next step. For 11, filtration of the Pd/C and removal of the solvent, affords a residue that is washed with acetone to provide pure 11. HMBC spectrum of 11a. was performed and the HMBC signals 3 J CH signals and 2 J CH signals were observed (not shown). In order to determine the regioselectivity of the Mannich reaction, compound 11a was analyzed by NOESY and HMBC. A weak NOE signal of N7-H and 6'-H, which is probably due to the quadrupole N7-H, in NOESY and the signal of 3J(C4-H5), as well as 3 J(C 5 or C 9 - H 3 or H 7 ) in HMBC (not shown), confirmed 11a with the amiomethyl substitution at the 6-position.
Reference: [1] Patent: WO2017/31176, 2017, A1, . Location in patent: Page/Page column 83-84
  • 24
  • [ 63026-85-7 ]
  • [ 1538-75-6 ]
  • [ 137281-08-4 ]
Reference: [1] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 18, p. 3025 - 3031
  • 25
  • [ 39856-58-1 ]
  • [ 1538-75-6 ]
  • [ 116026-98-3 ]
Reference: [1] Patent: WO2009/140642, 2009, A2, . Location in patent: Page/Page column 85
  • 26
  • [ 14044-63-4 ]
  • [ 1538-75-6 ]
  • [ 149990-27-2 ]
Reference: [1] Organic Letters, 2014, vol. 16, # 1, p. 94 - 97
  • 27
  • [ 110-91-8 ]
  • [ 1538-75-6 ]
  • [ 220199-85-9 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012, vol. 51, # 8, p. 1168 - 1172,5
  • 28
  • [ 96-50-4 ]
  • [ 1538-75-6 ]
  • [ 170961-15-6 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012, vol. 51, # 8, p. 1168 - 1172,5
  • 29
  • [ 18621-17-5 ]
  • [ 1538-75-6 ]
  • [ 141699-55-0 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogen In ethyl acetate for 24 h; 1-Benzhydryl-azetidin-3-ol 9a (4.0 g, 16.7 mmole), EtOAc (150 [ML),] [DI-TERT-BUTYL] dicarbonate (4.4 g, 20.1 [MMOLE)] and 20percent Pd (OH) 2 on carbon (0.8 g, 20 wt. percent) were sequentially added to a round bottom flask. The mixture was degassed and purged with hydrogen. The hydrogenolysis was completed after 24 hours at one atmosphere. The reaction mixture was filtered through celite and concentrated, in vacuo, to a clear oil (7.0 g). The crude product was dissolved in [CH2CI2] (10 ml) and purified over a silica gel plug (35 [G),] which was eluted with CH2CI2 (150 [ML) FOLLOWED] by EtOAc (150 [ML).] The EtOAc fractions were concentrated, in vacuo, to a clear oil (3.1 g, >100percent) : TLC (50percent ethyl acetate- cyclohexane) [R,] 0.4 [(12] stain) [; 1H-NMR (DMSO-D6,] 300 MHz) 8 5.62 (1 H, d, J = 6.4 Hz), 4.39- 4.32 (1 H, m), 3.97 (2H, t, J = 7.8 Hz), 3.57 (2H, t, J = 4.4 [HZ),] 1.35 (9H, s).
Reference: [1] Patent: WO2003/106462, 2003, A1, . Location in patent: Page 45; 46
  • 30
  • [ 1538-75-6 ]
  • [ 95-55-6 ]
  • [ 186663-74-1 ]
Reference: [1] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2012, vol. 51, # 8, p. 1168 - 1172,5
  • 31
  • [ 929-75-9 ]
  • [ 1538-75-6 ]
  • [ 101187-40-0 ]
YieldReaction ConditionsOperation in experiment
34% With triethylamine In dichloromethane for 4 h; To 2- [2- [2- [2-AMINOETHOXY] ethoxy] ethoxy] ethylamine (23 (, 0.5 g, 2.6 mmol), dissolved in CH2C12 (50 mL), was added triethylamine (0.36 mL, 100 molpercent) and Boc20 (0. 55 g, 100 molpercent). The reaction mixture was stirred for 4 hours and concentrated to dryness. The resulting residue was purified by silica gel column chromatography eluting with 9: 1: 0.1 chloroform : methanol: ammonium hydroxyde to give 0.26 g (34percent yield) of the title compound 24. H NMR (CDC13, 300 MHz) 8 3.66 (m, 8H), 3.57 (m, 4H), 3.28 (m, 2H), 2.90 (t, 2H), 1.63 (bs, 2H), 1.47 (s, 9H).
Reference: [1] Patent: WO2005/30258, 2005, A2, . Location in patent: Page/Page column 115
  • 32
  • [ 18650-38-9 ]
  • [ 1538-75-6 ]
  • [ 164456-75-1 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 2, p. 184 - 187
  • 33
  • [ 50541-93-0 ]
  • [ 1538-75-6 ]
  • [ 73889-19-7 ]
Reference: [1] Patent: US6235730, 2001, B1,
  • 34
  • [ 4246-51-9 ]
  • [ 1538-75-6 ]
  • [ 194920-62-2 ]
Reference: [1] Patent: WO2008/75192, 2008, A2, . Location in patent: Page/Page column 61-62
  • 35
  • [ 1538-75-6 ]
  • [ 714273-83-3 ]
Reference: [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1056 - 1071
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 6, p. 1416 - 1419
[3] Patent: CN107011331, 2017, A,
[4] Patent: CN107011322, 2017, A,
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 1538-75-6 ]

Aliphatic Chain Hydrocarbons

Chemical Structure| 14002-73-4

[ 14002-73-4 ]

Ethyl 3-hydroxy-2,2-dimethylpropanoate

Similarity: 0.88

Chemical Structure| 1115-20-4

[ 1115-20-4 ]

3-Hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropanoate

Similarity: 0.88

Chemical Structure| 51690-77-8

[ 51690-77-8 ]

3-Hydroxy-2,2-bis(hydroxymethyl)propyl propionate

Similarity: 0.88

Chemical Structure| 29138-64-5

[ 29138-64-5 ]

Butyric 2,2-dimethylbutanoic anhydride

Similarity: 0.86

Chemical Structure| 1619-62-1

[ 1619-62-1 ]

Diethyl 2,2-dimethylmalonate

Similarity: 0.85

Acid Anhydrides

Chemical Structure| 29138-64-5

[ 29138-64-5 ]

Butyric 2,2-dimethylbutanoic anhydride

Similarity: 0.86

Chemical Structure| 123-62-6

[ 123-62-6 ]

Propionic anhydride

Similarity: 0.83

Chemical Structure| 17347-61-4

[ 17347-61-4 ]

2,2-Dimethylsuccinicanhydride

Similarity: 0.83

Chemical Structure| 33993-24-7

[ 33993-24-7 ]

Cyclopropanecarboxylic anhydride

Similarity: 0.82

Chemical Structure| 84131-91-9

[ 84131-91-9 ]

(S)-2-Methylbutanoic anhydride

Similarity: 0.82