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Chemical Structure| 15384-39-1 Chemical Structure| 15384-39-1

Structure of 15384-39-1

Chemical Structure| 15384-39-1

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Product Details of [ 15384-39-1 ]

CAS No. :15384-39-1
Formula : C7H10N2O
M.W : 138.17
SMILES Code : NNC1=CC=CC(OC)=C1
MDL No. :MFCD02656657

Safety of [ 15384-39-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H318-H335
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of [ 15384-39-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15384-39-1 ]

[ 15384-39-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21168-41-2 ]
  • [ 15384-39-1 ]
  • 8-chloro-2-(3-methoxyphenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% With triethylamine; In N,N-dimethyl acetamide; at 140℃; for 16h; In a 8 mL-vial with magnetic stirrer and screw cap, ethyl 4,8-dichloroquinoline-3- carboxylate (135mg, 0.5 mmol, 1 equiv.), 3-(methoxy)phenyl hydrazine (83mg, 0.6 mmol, 1.2 equiv.) and triethylamine (61 mg, 0.6 mmol, 1.2 equiv.) were dissolved in dry N,N- dimethylacetamide (3 mL). The reaction mixture was heated to 140C for 16 hours. After completion of the reaction evaporation of volatiles and washing of the solid residue with acetone and water afforded the pure product. Yield: 66 % (0.33 mmol, 108 mg), Appearance: yellow solid, M.p.: ~ 340C, with partial decomposition above 300C, 1H NMR (200 MHz, DMSO-d6): 12.95 (bs, 1H), 8.72 (d, J = 5.2Hz, 1H), 8.15 (s, 1H), 7.84 - 7.70 (m, 4H), 7.33 (t, J = 8.1Hz, 1H), 6.75 (d, J = 8.1Hz, 1H), 3.80 (s, 3H).13C NMR (50 MHz, DMSO-d6): delta= 161.5 (s), 159.5 (s), 141.9 (s), 141.0 (s), 139.5 (d), 134.2 (s), 130.6 (s), 130.2 (d), 129.5 (d), 121.6 (d), 121.1 (d), 119.9 (s), 110.9 (d), 109.5 (d), 106.3 (s), 104.4 (d), 55.1 (q). HR-MS: [M+H]+ m/z (predicted) = 326.0691, m/z (measured) = 326.0688, difference = - 0.92 ppm.
 

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