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Chemical Structure| 154464-26-3 Chemical Structure| 154464-26-3

Structure of 154464-26-3

Chemical Structure| 154464-26-3

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Product Details of [ 154464-26-3 ]

CAS No. :154464-26-3
Formula : C12H17NO2
M.W : 207.27
SMILES Code : NC1=CC=C(OC)C(OC2CCCC2)=C1
MDL No. :MFCD00219843

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Application In Synthesis of [ 154464-26-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 154464-26-3 ]

[ 154464-26-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13958-93-5 ]
  • [ 154464-26-3 ]
  • 3,5-dichloro-N-(3-(cyclopentyloxy)-4-methoxyphenyl)pyridine-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
8.5% With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; To a solution of compound I-72a (600 mg, 2.88 mmol) in DMF (30 mL) wasadded EDC.HCI (1 .1 g, 5.76 mmol), HOBt (780 mg, 5.76 mmol), KR-i (550mg, 2.88 mmol), NMM (870 mg, 8.64 mmol). The mixture was stirred at r.t.overnight. The mixture was diluted with EA and washed with brine, dried over anhydrous Na2SO4 and concentrated to give the crude compound which was purified by column chromatography (EA:PE=1 :30-1 :3) and recrystallization (EA) to give I-75a (5-01, 85 mg, 8.5% yield) as a pale solid. ESI-MS (Mi-i):382.0 (HPLC Method: 3) calc. for C18H18C12N203: 381 .2.
 

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