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Chemical Structure| 1552301-50-4 Chemical Structure| 1552301-50-4

Structure of 1552301-50-4

Chemical Structure| 1552301-50-4

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Product Details of [ 1552301-50-4 ]

CAS No. :1552301-50-4
Formula : C8H7BrN4
M.W : 239.07
SMILES Code : NC1=NC(C)=C(C=C(Br)C=N2)C2=N1
MDL No. :MFCD28405245

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Application In Synthesis of [ 1552301-50-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1552301-50-4 ]

[ 1552301-50-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1083326-75-3 ]
  • [ 1552301-50-4 ]
  • N-(5-(2-amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl)methanesulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 4h;Inert atmosphere; General procedure: To a mixture of compound6(80 mg, 0.33 mmol), (6-methoxypyridin-3-yl)boronic acid (61 mg, 0.40 mmoland 2N aqueous K2CO3solution (0.5 mL, 1.0 mmol) in degassed DMF (5 mL) was addedPd(PPh3)2Cl2(12 mg, 0.017 mmol). The resulting mixture was degassed and back-filled with argon (three cycles), and then stirred at 100C under argon atmosphere for 4 hours. After cooling to room temperature, silica gel was added and the resulting mixture was evaporatedin vacuoto remove the volatiles. The residue was purified by flash column chromatography (silica gel,DCM/methanol/ammonium hydroxide = 600:10:1)to afford thetitle compound1as a yellow solid (71 mg, 81% yield).
  • 2
  • [ 1552301-50-4 ]
  • [ 628692-15-9 ]
  • 6-(2-methoxypyrimidin-5-yl)-4-methylpyrido[2,3-d]pyrimidin-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
56% With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 100℃; for 4h;Inert atmosphere; General procedure: To a mixture of compound 6 (80 mg, 0.33 mmol), (6-methoxypyridin-3-yl)boronic acid (61 mg, 0.40 mmol and 2N aqueous K2CO3 solution (0.5 mL, 1.0 mmol) in degassed DMF (5 mL) was added Pd(PPh3)2Cl2 (12 mg, 0.017 mmol). The resulting mixture was degassed and back-filled with argon (three cycles), and then stirred at 100C under argon atmosphere for 4 hours. After cooling to room temperature, silica gel was added and the resulting mixture was evaporated in vacuo to remove the volatiles. The residue was purified by flash column chromatography (silica gel,DCM/methanol/ammonium hydroxide = 600:10:1) to afford the title compound 1 as a yellow solid (71 mg, 81percent yield).
 

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