Alternatived Products of [ 15563-40-3 ]
Product Details of [ 15563-40-3 ]
CAS No. : | 15563-40-3 |
MDL No. : | |
Formula : |
C12H15NS
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
205.32
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 15563-40-3 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 15563-40-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 15563-40-3 ]
- Downstream synthetic route of [ 15563-40-3 ]
- 1
-
[ 15563-40-3 ]
-
[ 18233-24-4 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
2: 99 percent / pyridine / 16 h / Ambient temperature |
|
- 2
-
[ 15563-40-3 ]
-
[ 2905-56-8 ]
Yield | Reaction Conditions | Operation in experiment |
90% |
With bromopentacarbonylmanganese(I); hydrogen; triethylamine; copper(I) bromide; at 100℃; under 22502.3 Torr; for 1h;Autoclave; |
Into a 14mL polytetrafluoroethylene lined reaction tube, add the catalyst pentacarbonyl manganese bromide (0.0375mmol, 10.3mg),Reaction substrate N-thiobenzoyl piperidine (0.5mmol, 102.5mg), cuprous bromide (1.25mmol, 180mg), solvent hexafluoroisopropanol (2.5mL) and triethylamine (1.5mmol, 151.5 mg), place the reaction tube in the autoclave and fill it with 3MPa hydrogen.React at 100 C., after 1 hour, cool to room temperature, release gas, rinse the reaction tube with ethyl acetate, pass through a short silica gel column, and spin dry.After purification by column chromatography (eluent: petroleum ether: triethylamine = 40/1, v/v), 78 mg of the target product (formula I-a) was obtained, and the yield was 90%. |
- 3
-
[ 15563-40-3 ]
-
[ 488832-69-5 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
2: hydrogen sulfide / ethanol
3: sodium hydroxide
4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide; dichloromethane / 0 - 20 °C |
|
Reference:
[1]Chen, Shoujun; Sun, Lijun; Koya, Keizo; Tatsuta, Noriaki; Xia, Zhiqiang; Korbut, Timothy; Du, Zhenjian; Wu, Jim; Liang, Guiqing; Jiang, Jun; Ono, Mitsunori; Zhou, Dan; Sonderfan, Andrew
[Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 18, p. 5070 - 5076]
- 4
-
[ 110-89-4 ]
-
[ 150-60-7 ]
-
[ 15563-40-3 ]
Yield | Reaction Conditions | Operation in experiment |
89% |
With sulfur; dimethyl sulfoxide at 80℃; for 16h; Inert atmosphere; |
|
87% |
With iodine In dimethyl sulfoxide at 100℃; for 8h; |
(17) General Procedure for the Preparation of 3
General procedure: Iodine (0.25 mmol, 63.4 mg) and 1,2-dibenzyldisulfane (0.5mmol, 123.4 mg) was added to a solution of 1-methylpiperazine(1.2 mmol, 119.1 mg) in DMSO (0.5 mL), and the reactionmixture was stirred for 8 h at 100 °C. The solvent was removedunder vacuum, and the residue was purified by flash silica gelcolumn chromatography with PE-EtOAc (1:1) as eluent to affordthe product 3a. |
Reference:
[1]Nguyen, Thanh Binh; Nguyen, Le Phuong Anh; Nguyen, Thi Thu Tram
[Advanced Synthesis and Catalysis, 2019, vol. 361, # 8, p. 1787 - 1791]
[2]Chen, Sihai; Li, You; Chen, Jinyang; Xu, Xinhua; Su, Lebin; Tang, Zhi; Au, Chak-Tong; Qiu, Renhua
[Synlett, 2016, vol. 27, # 16, p. 2339 - 2344]