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Chemical Structure| 155989-69-8 Chemical Structure| 155989-69-8

Structure of 155989-69-8

Chemical Structure| 155989-69-8

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Product Details of [ 155989-69-8 ]

CAS No. :155989-69-8
Formula : C16H23NO3
M.W : 277.36
SMILES Code : O=C(N1CCC(OC2=CC=CC=C2)CC1)OC(C)(C)C
MDL No. :MFCD14706085

Safety of [ 155989-69-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 155989-69-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 155989-69-8 ]

[ 155989-69-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 155989-69-8 ]
  • [ 3202-33-3 ]
YieldReaction ConditionsOperation in experiment
96% With trifluoroacetic acid; In dichloromethane; at 20℃; for 2.5h; tert-Butyl 4-phenoxypiperidine-1-carboxylate (453 mg) was dissolved in dichloromethane (10 mL).TFA (1.4 mL) was added and the mixture was stirred at room temperature for 2.5 h. The reactionmixture was concentrated and re-dissolved in dichloromethane (20 mL), followed by washingwith 1.5 M NaOH (20 mL). The water phase was extracted with 2 20 mL DCM. The combinedorganic phases were dried over Na2SO4, filtered and concentrated. Purification with flash columnchromatography using 5% MeOH and 1% triethylamine (TEA) in DCM Product was isolated as awhite solid (290 mg, 96%). Rf = 0.18 (5% MeOH, 1% TEA in DCM). 1H-NMR (400 MHz, CDCl3) delta 7.30-7.25 (m, 2H), 6.96-6.89 (m, 3H), 4.39 (hept, J = 3.9 Hz, 1H), 3.20-3.12 (m, 2H), 2.80-2.72 (m, 2H),2.24 (br. s, 1H), 2.08-1.97 (m, 2H), 1.75-1.65 (m, 2H). 13C-NMR (101 MHz, CDCl3) delta 157.4, 129.6, 121.0,116.3 73.1, 43.8, 32.2. HPLC purity > 99%.
 

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